Accepted

This article presents studies on the pharmacokinetics of oxycodone hydrochloride and the influence of micronized magnesium lactate on its bioavailability and pharmacokinetic parameters. Two methods, HPLC-DAD, and HPLC-MS/MS, were developed […]

Chronic prostatitis/Chronic pelvis pain syndrome (CP/CPPS), a kind of frequent urinary condition among adult males, has caused a lot of inconvenience to patients in life, whose pathogenesis is unclear. Current […]

Intervertebral disc degeneration (IVDD) is a significant contributor to low back pain (LBP); however, the specific mechanisms involved remain unclear. Herein, a novel LBP mouse model was developed by integrating […]

Pain, or the ability to feel pain and express the unpleasantness caused by peripheral injuries, are functions of the central nervous system. From peripheral sensory nerve terminals to certain cortical […]

Studies examining the interplay between chronic pain, cognitive function, and functional brain abnormalities in older adults are scarce. To address this gap, we administered a series of neuropsychological tests and […]

Pathological pain is defined as pain that outlives its usefulness as a protective warning system and becomes debilitating, disrupting normal life function. Understanding the mechanism of transition from physiological to […]

While the comorbidity of migraine and multiple sclerosis (MS) has been documented, large-scale studies examining migraine patterns in MS patients, particularly across diverse age ranges, are scarce. This study aimed […]

Diabetic neuropathy (DN) is microvascular issues caused by diabetes mellitus (DM) that damages peripheral nerve system. DN-induced pain progression and persistence occur due to many risk factors, including as increased […]

Migraine is a neurological disorder linked to altered cortical excitability. High-frequency repetitive transcranial magnetic stimulation (HF-rTMS) is a promising non-invasive method for modulating nociceptive circuits, yet its precise mechanisms remain […]