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Mirikizumab: A New Therapeutic Option for the Treatment of Ulcerative Colitis.

To review the pharmacologic and clinical profile of mirikizumab in the treatment of moderate to severe ulcerative colitis (UC).

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Multi-omics analyses uncover metabolic signatures and gene expression profiles of interstitial cystitis/bladder pain syndrome.

We explore molecular and metabolic pathways involved in interstitial cystitis (IC) with integrating multi-omics analysis for identifying potential diagnostic and therapeutic targets.

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Insight gained from using animal models to study pain in Parkinson’s disease.

Pain is one of the key non-motor symptoms experienced by a large proportion of people living with Parkinson’s disease (PD), yet the mechanisms behind this pain remain elusive and as […]

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Pain and diet: A summary of the evidence for the role of diet modification in chronic pain.

Chronic pain constitutes a significant burden to patients and healthcare systems. For many patients, the only option is to attempt to manage their pain within their daily lives. Here, we […]

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Is there an association between lateralization of chronic pain in the body and depression?

Depression commonly co-occurs with chronic pain and can worsen pain outcomes. Recent theoretical work has hypothesized that pain localized to the left hemibody is a risk factor for worse depression […]

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Topical capsaicin 8% patch in peripheral neuropathic pain: Efficacy and quality of life.

Peripheral neuropathic pain (PNP) is one of the most challenging diseases to treat with a significant negative impact on the patients’ health-related quality of life (HRQoL). Capsaicin 8% patch has […]

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Thrombospondin 4, a mediator and candidate indicator of pain.

Pain is the most common symptom for which patients seek medical attention. Existing treatments for pain control are largely ineffective due to the lack of an accurate way to objectively […]

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Practicing self-hypnosis to reduce chronic pain: A qualitative exploratory study of HYlaDO.

: Nearly a quarter of Canada’s population suffers from chronic pain, a long-lasting medical condition marked by physical pain and psychological suffering. Opioids are the primary treatment for pain management […]

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Influence of metabolic state and body composition on the action of pharmacological treatment of migraine.

Migraine is a disabling neurovascular disorder among people of all ages, with the highest prevalence in the fertile years, and in women. Migraine impacts the quality of life of affected […]

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Combined Transcriptomic and Proteomic Profiling of the Mouse Anterior Cingulate Cortex Identifies Potential Therapeutic Targets for Pulpitis-Induced Pain.

Pulpitis is a common dental emergency that presents with intense pain; there is still no specific medicine to treat pulpitis-induced pain to date. Herein, differentially expressed genes in mouse anterior […]

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