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Nanostructured lipid carriers in Rheumatoid Arthritis: treatment, advancements and applications.

Rheumatoid arthritis (RA) is a chronic autoimmune disease that affects the joints and causes pain, swelling, and deformity. Current treatments, including nonsteroidal anti-inflammatory drugs (NSAIDs), corticosteroids, and disease-modifying antirheumatic drugs, […]

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Notopterol mitigates osteoarthritis progression and relieves pain in mice by inhibiting PI3K/Akt/GPX4-mediated ferroptosis.

Ferroptosis-induced lipid peroxidation in chondrocytes exacerbates intra-articular inflammation, oxidative stress, and articular cartilage degradation, accelerating osteoarthritis (OA) progression. Effective anti-inflammatory and antioxidant interventions can alleviate both joint pain and cartilage […]

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Follistatin, A Novel Therapeutic Target for Chronic Pain.

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Baseline Functional Connectivity of the Mesolimbic, Salience, and Sensorimotor Systems Predicts Responses to Psychological Therapies for Chronic Low Back Pain With Comorbid Depression: A Functional MRI Study.

Chronic low back pain (CLBP) is a prevalent and debilitating condition. Cognitive behavioral therapy (CBT) can improve coping mechanisms for CLBP and pain-related outcomes. However, the mechanisms by which they […]

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Modulating neuroplasticity for chronic pain relief: noninvasive neuromodulation as a promising approach.

Chronic neuropathic pain is a debilitating neuroplastic disorder that notably impacts the quality of life of millions of people worldwide. This complex condition, encompassing various manifestations, such as sciatica, diabetic […]

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Clinical Application of Intelligent Pain Management Program in Patients With Postherpetic Neuralgia Patients.

Effective pain management is crucial for treating and caring for individuals with postherpetic neuralgia (PHN). A systematic pain management program for this condition has not been established.

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Decoding the mechanism of proanthocyanidins in central analgesia: redox regulation and KCNK3 blockade.

Neuropathic pain causes enduring physical discomfort and emotional distress. Conventional pharmacological treatments often provide restricted relief and may result in undesirable side effects, posing a substantial clinical challenge. Peripheral and […]

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Antipruritic Effects of Single Administration of Paroxetine on Acute and Chronic Itch.

Itch is described as an unpleasant sensation, and chronic itch, such as that in atopic dermatitis (AD), often decreases a patient’s QOL. There are few effective treatments for various chronic […]

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Ultrafast optical imaging techniques for exploring rapid neuronal dynamics.

Optical neuroimaging has significantly advanced our understanding of brain function, particularly through techniques such as two-photon microscopy, which captures three-dimensional brain structures with sub-cellular resolution. However, traditional methods struggle to […]

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Epidemiology and clinical features of occipital neuralgia: A systematic review and meta-analysis.

Occipital neuralgia (ON) describes severe, paroxysmal occipital nerve pain. This review synthesizes data on the epidemiology and clinical features of ON.

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