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Research waste in randomised trials of exercise treatments for chronic low back pain: trial sequential and cumulative meta-analyses by publication date and size.

To determine if there is research waste in controlled trials of exercise therapies compared with usual care/no treatment for adults with chronic non-specific lower back pain.

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A comprehensive protocol for simplified mouse DRG fixation, processing and F4/80 immunohistochemistry: Overcoming common challenges.

Dorsal root ganglia (DRGs) contain the cell bodies of sensory neurons and non-neuronal cells that play a role in the pathophysiology of painful inflammatory conditions, such as neuropathic pain. Immunohistochemistry […]

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Integrating Data Mining with Transcranial Focused Ultrasound to Refine Neuralgia Treatment Strategies.

Neuralgia and other neuropathic pain are difficult to treat owing to their complicated etiology and a wide variety of responses to treatment. The novel neuromodulation technology transcranial focused ultrasound (tFUS) […]

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A pontine center in descending pain control.

Pain sensation changes according to expectation, context, and mood, illustrating how top-down circuits affect somatosensory processing. Here, we used an intersectional strategy to identify anatomical and molecular-spatial features of supraspinal […]

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Enteric neuronal Piezo1 maintains mechanical and immunological homeostasis by sensing force.

The gastrointestinal (GI) tract experiences a myriad of mechanical forces while orchestrating digestion and barrier immunity. A central conductor of these processes, the enteric nervous system (ENS), detects luminal pressure […]

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Blockade of IgG Fc receptors reduces pain after intervertebral disc injury.

Intervertebral disc (IVD) injury is a common cause of low back pain and disability. Recent evidence suggests that autoantibodies contribute to such pain. We, therefore, explored the hypothesis that a […]

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Bioinformatic strategies in metagenomics of chronic prostatitis.

Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is a prevalent urological condition in young men, significantly affecting quality of life due to persistent discomfort and neuropsychological symptoms. Despite its high prevalence, […]

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The Impact of Biseasonal Time Changes on Migraine.

: Changes in the daily rhythm can trigger migraine attacks. The sensitivity for triggering attacks is closely linked to the regulation of biological rhythms controlled by the hypothalamus. In over […]

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Are Chronic Pain Fellowships Disguised as Acute Pain Fellowships Which Manage Chronic Pain? How to Recognize and Repair.

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Hyperalgesic Priming in the Transition From Acute to Chronic Pain: Focus on Different Models and the Molecular Mechanisms Involved.

Poorly treated acute pain can develop into chronic pain, resulting in significant impairment of patients’ quality of life. The hyperalgesic priming model is commonly used to study how acute pain […]

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