Accepted

Pain empathy, defined as the ability of one person to understand another person’s pain, shows large individual variations. The anterior insula is the core region of the pain empathy network. […]

The objective of this study is to utilize Mendelian Randomization to scrutinize the mutual causality between migraine and Venous Thromboembolism (VTE) thereby addressing the heterogeneity and inconsistency that were observed […]

MDMA (3,4-methylenedioxymethamphetamine) is a psychoactive drug with powerful prosocial effects. While MDMA is sometimes termed an “empathogen,” empirical studies have struggled to clearly demonstrate these effects or pinpoint underlying mechanisms. […]

Neck pain is a common condition that leads to neck motor dysfunction and subsequent disability, with a significant global health care burden. As a newly emerging tool, virtual reality (VR) […]

Chronic local inflammation and excessive cell apoptosis in nucleus pulposus (NP) tissue are the main causes of intervertebral disc degeneration (IDD). Stimuli-responsive hydrogels have great potential in the treatment of […]

It is usually assumed that an individual’s classification as a patient or a healthy person is determined by the presence or absence of disease, but little is known about whether […]

Diabetic peripheral neuropathic pain (DPNP) and postherpetic neuralgia (PHN) are challenging and often intractable complex medical conditions, with a substantial impact on the quality of life. Mirogabalin, a novel voltage-gated […]

Studies have suggested that microglial IL-6 modulates inflammatory pain; however, the exact mechanism of action remains unclear. We therefore hypothesized that PKCε and MEG2 competitively bind to STAT3 and contribute […]

Does linzagolix administered orally once daily for up to 3 months at a dose of 75 mg alone or 200 mg in combination with add-back therapy (ABT) (1.0 mg estradiol; 0.5 mg norethindrone acetate, also […]

Vulvodynia (VVD) is a debilitating chronic vulvar pain significantly affecting patients’ quality of life. Interstitial cystitis/bladder pain syndrome (IC/BPS) is a chronic and complex illness characterized by an unpleasant sensation […]