Accepted

Transient Receptor Potential Vanilloid 3 (TRPV3) is a thermosensitive calcium-permeable ion channel and has a function in sensory perception, epidermal barrier function, inflammation, and keratinocyte proliferation. TRPV3 dysfunction is linked […]

Secondary spinal cord injury (SCI) is characterized by increased cytokines and chemokines at the site of injury that have been associated with the development of neuropathic pain. Nearly 80% of […]

Genetic loss-of-function mutations of the Na1.7 channel, abundantly expressed in peripheral nociceptive neurons, cause congenital insensitivity to pain in humans, indicating that selective inhibition of the channel may lead to […]

With the current pressure to reduce opioid usage in the clinical setting, there is a call for the development of adjunct therapies. Although opioids remain the primary analgesic used in […]

Intrathecal catheterization has been widely applied in animal experiments, especially those on neuropathic pain. However, the traditional methods still have several limitations. Although some investigators have attempted to improve the traditional […]

A growing body of evidence suggests a correlation among immune cells, serum micronutrient levels, and neuropathic pain. However, previous studies have been limited in scope, hindering the establishment of conclusive […]

Painful bladder syndrome and irritable bowel syndrome affect 10%-15% of the global population. Current treatment options for these syndromes are ineffective in severe disease progression and are fraught with adverse […]

Perception of pain offset is essential to free one from any aftereffects of nociception. Because patients with chronic pain show impaired temporal contrast of pain, we tested whether they show […]

Pro-inflammatory mediators can directly activate pain-sensing neurons, known as nociceptors. Additionally, these mediators can sensitise ion channels and receptors expressed by these cells through transcriptional and post-translational modulation, leading to […]