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LAST-PAIN: Learning Adaptive Spike Thresholds for Low Back Pain Biosignals Classification.

Spiking neural networks (SNNs) present the potential for ultra-low-power computation, especially when implemented on dedicated neuromorphic hardware. However, a significant challenge is the efficient conversion of continuous real-world data into […]

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Factors influencing the hypoalgesic effects of virtual reality.

Virtual reality (VR) is a promising intervention for both experimentally induced and clinical pain, but the factors contributing to the efficacy of VR remain relatively unclear, partially because selecting adequate […]

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Sex differences in age-associated neurological diseases-A roadmap for reliable and high-yield research.

Once taken into consideration, sex differences in neurological diseases emerge in abundance: (i) Stroke severity is significantly higher in females than in males, (ii) Alzheimer’s disease (AD) pathology is more […]

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E. B. Hershberg Award: Taming Inflammation by Tuning Purinergic Signaling.

ConspectusThe author presents his personal story from early contributions in purinergic receptor research to present-day structure-guided medicinal chemistry. Modulating purinergic signaling (encompassing pyrimidine nucleotides as well) and other nucleoside targets […]

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Biogenic Nickel Oxide Nanoparticles: Synthesis, Characterization and Biomedical Potential.

Green-synthesized nanoparticles provide an eco-friendly approach to nanotechnology, reducing harmful chemical use and environmental impact. This study focuses on the green synthesis of nickel oxide nanoparticles (FV-NiO NPs) using Fioria […]

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The presence and prognosis of nerve pathology following whiplash injury: a prospective cohort study.

Whiplash Associated Disorders (WAD) affect 20-50 million individuals globally each year, with up to 50% developing persistent pain. WAD grade II (WADII) is the most common type and is characterised […]

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Identification and Experimental Verification of Potential Immune Cell-Associated Gene Biomarkers in Human Intervertebral Disc Degeneration.

Intervertebral disc degeneration (IDD) is one of the most common diseases in the elderly population. Recently, immune disorders have been considered to play an important role in IDD. This study […]

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Altered gut microbiome composition and function in individuals with complex regional pain syndrome.

Complex regional pain syndrome (CRPS) is a chronic pain syndrome typically affecting a limb. It is characterized by severe spontaneous and evoked pain, along with vasomotor, autonomic, and motor signs […]

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Precipitating Factors for Functional Cognitive Disorder.

The underlying mechanisms of functional cognitive disorder (FCD) are still poorly understood. This hinders diagnostic identification and establishment of personalised and effective treatments. We aimed to describe the precipitating factors […]

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Pain without presence: a narrative review of the pathophysiological landscape of phantom limb pain.

Phantom limb pain (PLP) is defined as the perception of pain in a limb that has been amputated. In the United States, approximately 30,000-40,000 amputations are performed annually with an […]

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