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Synchronization of a Virtual Reality Scenario to Uterine Contractions for Labor Pain Management: Development Study and Randomized Controlled Trial.

Labor is described as one of the most painful events women can experience through their lives, and labor pain shows unique features and rhythmic fluctuations. The present study aims to […]

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Hypersensitivity to CGRP as a predictive biomarker of migraine prevention with erenumab.

The present study aimed to investigate the predictive value of calcitonin gene-related peptide (CGRP)-induced migraine attacks for effectiveness to erenumab treatment in people with migraine.

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Mitigation of experimental ER stress and diabetes mellitus induced peripheral neuropathy by autophagy promoter, 6-BIO.

Neuropathy occurs due to damage to the peripheral/central nervous system either due to injury, disease, or drug usage. Increased endoplasmic reticulum (ER) stress is observed in neuropathy. ER stress also […]

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Loss of sigma-2 receptor/TMEM97 is associated with neuropathic injury-induced depression-like behaviors in female mice.

Previous studies have shown that ligands that bind to sigma-2 receptor/TMEM97 (σR/TMEM97), a transmembrane protein, have anxiolytic/antidepressant-like properties and relieve neuropathic pain-like effects in rodents. Despite medical interest in σR/TMEM97, […]

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MicroRNA-6954-3p down-regulation contributes to orofacial neuropathic pain in mice via targeting voltage-gated sodium channel β2 subunit protein.

The voltage-gated sodium channel β2 subunit protein (SCN2B) plays a crucial role in neuropathic pain. However, the role and mechanisms of SCN2B in orofacial neuropathic pain are still unclear. This […]

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Endoscopic management of greater trochanteric pain syndrome (GTPS): a comprehensive systematic review.

Greater trochanteric pain syndrome (GTPS) presents challenges in clinical management due to its chronic nature and uncertain etiology. Historically attributed to greater trochanteric bursitis, current understanding implicates abductor tendinopathy as […]

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Verbal support from a stranger reduces the development of mechanical hypersensitivity: behavioural and neurophysiological evidence.

Handholding reduces experimentally induced acute pain, and buffers against the development of mechanical secondary hypersensitivity, an indirect proxy of central sensitization. Here, we tested if verbal support from a stranger, […]

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Well-defined alginate oligosaccharides ameliorate joint pain and inflammation in a mouse model of gouty arthritis.

Gouty arthritis causes severe pain and inflammation. Alginate oligosaccharides (AOSs) are natural products derived from alginate and have anti-inflammatory properties. We explored the potential effects of AOSs with different degrees […]

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What’s the situation with ocular inflammation? A cross-seasonal investigation of proteomic changes in ocular allergy sufferers’ tears in Victoria, Australia.

Ocular allergy (OA) is a localized subset of allergy characterized by ocular surface itchiness, redness and inflammation. Inflammation and eye-rubbing, due to allergy-associated itch, are common in OA sufferers and […]

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Longitudinal Analysis of the Care Pathway of Patients with Lumbar Spinal Stenosis in the US.

Evidence regarding the frequency and timing of treatment for lumbar spinal stenosis (LSS) fails to offer clear consensus. We describe the LSS care journey from initial diagnosis to first surgical […]

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