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The fungal secretory peptide micasin induces itch by activating MRGPRX1/C11/A1 on peripheral neurons.

Pruritus is the leading symptom of dermatophytosis. Microsporium canis is one of the predominant dermatophytes causing dermatophytosis. However, the pruritogenic agents and the related molecular mechanisms of the dermatophyte M. […]

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Could relationship-based learnt beliefs and expectations contribute to physiological vulnerability of chronic pain? Making a case to consider attachment in pain research.

Pain is an interpersonal and inherently social experience. Pain perception and administration of medical treatment all occur in a particular environmental and social context. Early environmental influences, and early learning […]

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“Evidence-based” needs to be based on evidence – a response to Giddon’s letter regarding Edwards et al., Is there an association between lateralization of chronic pain in the body and depression?

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Brain network dynamics in women with primary dysmenorrhea during the pain-free periovulation phase.

The human brain is a dynamic system that shows frequency-specific features. Neuroimaging studies have shown that both healthy individuals and those with chronic pain disorders experience pain influenced by various […]

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Annual trends in pain management modalities in patients with newly diagnosed autoimmune rheumatic diseases in the USA from 2007 to 2021: an administrative claims-based study.

Autoimmune rheumatic diseases have distinct pathogenic mechanisms and are causes of disability and increased mortality worldwide. In this study, we aimed to examine annual trends in pain management modalities among […]

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An examination of referrals declined for chronic pain care: There is increasing mental health complexity within care-seeking patients with chronic pain over time.

Chronic pain is a complex disease that requires interprofessional care for effective management. Despite the need for multidisciplinary care, disease and health care inequities can prevent individuals from attaining adequate […]

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Chronic Nonbacterial Osteomyelitis in Children: Exploring the Interplay of Sleep, Pain, Quality of Life, and Disease Activity.

Chronic nonbacterial osteomyelitis (CNO) is an autoinflammatory bone disease that most commonly affects children and adolescents. Pain is a common problem in pediatric rheumatic diseases, with adolescents reporting reduced physical […]

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Pharmacotherapy for osteoarthritis-related pain: current and emerging therapies.

Osteoarthritis (OA) related pain has affected millions of people worldwide. However, the current pharmacological options for managing OA-related pain have not achieved a satisfactory effect.

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Novel insights into the multifaceted and tissue-specific roles of the endocytic receptor LRP1.

Receptor-mediated endocytosis provides a mechanism for the selective uptake of specific molecules thereby controlling the composition of the extracellular environment and biological processes. The low-density lipoprotein receptor-related protein 1 (LRP1) […]

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Identification of N-(((1S,3R,5S)-adamantan-1-yl)methyl)-3-((4-chlorophenyl)sulfonyl)benzenesulfonamide as novel Nav1.8 inhibitor with analgesic profile.

Chronic pain is a common and challenging clinical problem that significantly impacts patients’ quality of life. The sodium channel Nav1.8 plays a crucial role in the occurrence and development of […]

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