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What causes migraines? Study of ‘brain blackout’ offers clues.

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The limited role of serum neurofilament light chain in predicting pain severity of patients with diabetic polyneuropathy.

Pain is one of many complaints expressed by patients with diabetic polyneuropathy. However, no objective measure for pain severity has been available. Neurofilament light chains have been widely used for […]

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Targeting neuroinflammation in distal symmetrical polyneuropathy in diabetes.

Diabetic distal symmetric polyneuropathy is the most common type of peripheral neuropathy complication of diabetes mellitus. Neuroinflammation is emerging as an important contributor to diabetes-induced neuropathy. Long-term hyperglycemia results in […]

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How Does Neuromodulation for Neuropathic Pain Affect Euthanasia Requests? A Forethought on the Current Situation in Spain Is Needed.

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Chronic sleep deficiency and its impact on pain perception in healthy females.

Acute sleep deprivation in experimental studies has been shown to induce pain hypersensitivity in females. However, the impact of natural sleep deficiency and fluctuations across the week on pain perception […]

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Spinal Cord Stimulator Inequities Within the US Military Health System.

Although studies have described inequities in spinal cord stimulation (SCS) receipt, there is a lack of information to inform system-level changes to support health care equity. This study evaluated whether […]

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Vaginal and rectal microbiome contribute to genital inflammation in chronic pelvic pain.

Chronic pelvic pain (CPP) is a multifactorial syndrome that can substantially affect a patient’s quality of life. Endometriosis is one cause of CPP, and alterations of the immune and microbiome […]

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Differential Target Multiplexed Spinal Cord Stimulation: A UK Cost-Effectiveness Analysis.

The aim of this economic analysis was to evaluate the cost-effectiveness of differential target multiplexed spinal cord stimulation (DTM-SCS) for treating chronic intractable low back pain, compared with conventional spinal […]

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White matter and cortical gray matter microstructural abnormalities in new daily persistent headache: a NODDI study.

New daily persistent headache (NDPH) is a rare primary headache with unclear pathogenesis. Neuroimaging studies of NDPH are limited, and controversy still exists. Diffusion tensor imaging (DTI) is commonly used […]

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Inhibition of Mast Cell Degranulation by Novel Small Molecule MRGPRX2 Antagonists.

Mas-related G-protein coupled receptor X2 (MRGPRX2) is a promiscuous receptor on mast cells that mediates IgE-independent degranulation and has been implicated in multiple mast cell-mediated disorders, including chronic urticaria, atopic […]

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