Accepted

Chronic pain is a prevalent comorbidity among those with posttraumatic stress disorder (PTSD). Chronic pain can be divided into specific pain (i.e., involving a single body system) and complex pain […]

The mechanisms underlying Rheumatoid Arthritis (RA) remain unclear. Despite having relatively well-defined treatment strategies, current therapeutic approaches only achieve a remission rate of 70 %-80 %, with poor prognosis and no clear […]

In China, the drug treatment of many cancer pain patients is obviously affected by people’s lack of knowledge and confidence, and cancer pain symptoms fail to be effectively controlled. This […]

The subjective nature of pain complicates objective verification, often leading to noncredible symptom reports in compensable settings. Across two studies, we evaluated the Italian Self-Report Symptom Inventory (SRSI-It) in distinguishing […]

This study utilized a longitudinal survey in Japan to investigate whether higher Central Sensitization Inventory (CSI) scores, serving as a proxy for central sensitization-related symptoms, are associated with an increased […]

The trial-to-implant ratio for spinal cord stimulation (SCS) has long served as a cornerstone metric for optimizing patient selection and cost containment. Historically, screening trials played a pivotal role in […]

Spinal cord injury (SCI) causes persistent motor, sensory, psychological, and bladder dysfunctions, with clinical evidence indicating better recovery in females compared to males. However, the mechanisms driving these sex-specific differences […]

Mature adults often exhibit higher pain thresholds than younger individuals. However, this phenomenon is poorly understood, especially with regards to peripheral nervous system signaling.

Chemotherapy-induced peripheral neuropathy (CIPN) severely diminishes the quality of life for cancer survivors, yet effective treatments remain scarce. Esketamine, a commonly used anesthetic, has demonstrated neuroprotective effects by restoring gut […]

Morphine and other synthetic opioids are widely prescribed to treat pain. Prolonged morphine exposure can paradoxically enhance pain sensitivity in humans and nociceptive behavior in rodents. To better understand the […]