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Hematological biomarkers of systemic inflammation in predicting long-term treatment response of temporomandibular disorders.

Chronic systemic inflammation has been proposed as the underlying mechanism of pain chronicity in several pain conditions. In spite of the growing evidence supporting the role of systemic inflammatory markers […]

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Involvement of the cerebellum in structural connectivity enhancement in episodic migraine.

The pathophysiology of migraine remains poorly understood, yet a growing number of studies have shown structural connectivity disruptions across large-scale brain networks. Although both structural and functional changes have been […]

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PSD-95 Protein: A Promising Therapeutic Target in Chronic Pain.

Chronic pain, as a social public health problem, has a serious impact on the quality of patients’ life. Currently, the main drugs used to treat chronic pain are opioids, antipyretic, […]

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Neutrophils in Atopic Dermatitis.

Neutrophils have a critical role in inflammation. Recent studies have identified their distinctive presence in certain types of atopic dermatitis (AD), yet their exact function remains unclear. This review aims […]

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Baicalein ameliorates chronic itch in ACD mice by suppressing the spinal astrocytic STAT3-LCN2 cascade.

Chronic itch is a maladaptive and debilitating symptom in patients with allergic contact dermatitis (ACD), adversely affecting their quality of life. There is a lack of effective treatments for ACD-associated […]

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The impact of different music genres on pain tolerance: emphasizing the significance of individual music genre preferences.

Music is a promising (adjunctive) treatment for both acute and chronic pain, reducing the need for pharmacological analgesics and their side effects. Yet, little is known about the effect of […]

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Development and Validation of A Nomogram for Evaluating the Incident Risk of Pain Catastrophizing Among Patients Who Have Severe Knee Osteoarthritis Awaiting Primary Total Knee Arthroplasty.

It is clinically important to anticipate the likelihood of pain catastrophizing in patients who undergo total knee arthroplasty (TKA). Persistent pain and diminished physical function following TKA are independently associated […]

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Comparative effects of drug interventions for the acute management of migraine episodes in adults: systematic review and network meta-analysis.

To compare all licensed drug interventions as oral monotherapy for the acute treatment of migraine episodes in adults.

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The revised pediatric chronic pain grading: built on outdated foundations, overlooking newer pediatric versions.

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Defining pain-related suffering requires partnership with people living with pain and careful critical thought: a commentary on the proposed definition by Noe-Steinmüller et al.

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