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Working under the influence of cannabis amongst medical cannabis patients with chronic pain.

Cannabis use is increasing in the United States, and, on average, those consuming medical cannabis report more frequent cannabis use than those who use recreationally. The present analyses focus on […]

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Systematic review of pharmacotherapy for atypical facial pain: evaluation of pain reduction, depression, anxiety and quality of life.

Atypical facial pain (AFP) is a chronic condition characterized by persistent facial pain without clear clinical signs, making diagnosis and treatment difficult. Common pharmacological treatments include antidepressants, anticonvulsants and neuromodulators, […]

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Electrophysiological characteristics of neuropathic pain model in mice and a technique to evaluate peripheral nerve damage in the sciatic nerve.

Experimental neuropathic pain (NP) models were developed from peripheral injuries and are widely used for pain research. However, previously published methods and outcomes in the evaluation of sciatic nerve dysfunction […]

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The structural basis of the G protein-coupled receptor and ion channel axis.

Sensory neurons play an essential role in recognizing and responding to detrimental, irritating, and inflammatory stimuli from our surroundings, such as pain, itch, cough, and neurogenic inflammation. The transduction of […]

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Neurological impact of sub-chronic lead acetate exposure on pain perception in mice.

Lead exposure is a significant environmental health concern with potential impacts on pain perception and physiological functions. This study investigates the effects of sub-chronic lead acetate exposure on pain threshold, […]

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Investigating the causal impact of gut microbiota on trigeminal neuralgia: a bidirectional Mendelian randomization study.

The etiology and pathogenesis of trigeminal neuralgia remain unclear. This study examines the connection between gut microbiota and trigeminal neuralgia using Mendelian randomization analysis to provide insights into the disorder’s […]

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The Role of Thrombospondins in Osteoarthritis: from Molecular Mechanisms to Therapeutic Potential.

Osteoarthritis (OA) is a prevalent chronic degenerative joint disorder characterized by cartilage degeneration, joint inflammation, and pain. The pathogenesis of OA still remains unclear. Among the various factors contributing to […]

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Filtered and unfiltered lipoaspirates reveal novel molecular insights and therapeutic potential for osteoarthritis treatment: a preclinical in vitro study.

Orthobiologics, such as autologous nanofat, are emerging as a potential treatment option for osteoarthritis (OA), a common degenerative joint causing pain and disability in the elderly. Nanofat, a minimally processed […]

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Clinical application of repetitive transcranial magnetic stimulation in the treatment of chronic pelvic pain syndrome: a scoping review.

Chronic pelvic pain syndrome is a common condition characterized by persistent symptoms that are difficult to treat. Repetitive transcranial magnetic stimulation (rTMS) is considered a safe treatment option for alleviating […]

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Association Between Dietary Alcohol Intake and Migraine or Severe Headache Miscellaneous Pain: The NHANES 1999-2004.

The relationship between alcohol consumption and migraine or severe headache remains controversial in the existing literature. Given that alcohol is a widely consumed beverage, clarifying the relationship between alcohol and […]

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