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Development of the COMPASS model of endometriosis: A COmprehensive model of pain encompassing agency, systemic factors and sense making.

Endometriosis is a chronic and progressive condition commonly associated with debilitating pain. Treatments for endometriosis pain are limited and usually invasive. Psychological interventions are a non-invasive intervention option and have […]

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Exploring the Role of the Cerebellum in Pain Perception: A Narrative Review.

This systematic review aims to reassess the expanding role of the cerebellum in pain perception, challenging its traditional and simplistic association with the motor domain. Pain perception is a complex […]

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Continuous preparation of long-acting hydromorphone PLGA microspheres using an automatic and scalable microfluidic process system.

The long-acting hydromorphone loaded poly-lactic-co-glycolic acid (HM-PLGA) microspheres for chronic pain management were developed and prepared using an automatic and scalable microfluidic process system in this study. The system consists […]

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Behavioral outcomes in the bystander and demonstrator male mice following a socially-transferred allodynia paradigm.

The state of mechanical allodynia can be socially transferred from one individual to another during a brief empathetic contact. Our recent research has identified inter-individual differences in behavioral adaptations among […]

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A transcriptional atlas of gut-innervating neurons reveals activation of interferon signaling and ferroptosis during intestinal inflammation.

Enteric infections often cause long-term sequelae, including persistent gastrointestinal symptoms, such as pain, discomfort, or irritable bowel syndrome. The plethora of sensory symptoms indicates that gut-innervating neurons might be directly […]

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Phenyl-benzyl-ureas with pyridazinone motif: Potent soluble epoxide hydrolase inhibitors with enhanced pharmacokinetics and efficacy in a paclitaxel-induced neuropathic pain model.

The severe pain linked to chemotherapy-induced peripheral neuropathy (CIPN) often becomes a critical factor limiting the effective dosage of life-saving chemotherapy treatments. This debilitating side effect not only hampers the […]

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Beyond association: strengthening causal evidence between childhood trauma and chronic widespread pain.

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Chronic pain in European adult populations: a systematic review of prevalence and associated clinical features.

Chronic pain (CP) is a multifaceted and severely disabling persistent condition that affects individuals worldwide. A synthesis of epidemiological data is still lacking. The present systematic review aims at presenting […]

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Chitosan stabilized platinum nanoparticles: In vitro and in vivo screening for analgesic and anti-inflammatory applications.

In this interdisciplinary research work, the chitosan stabilized platinum nanoparticles are synthesized through the wet chemical method, and the structural, surface morphological, and optical characterizations are done using X-ray crystallography, […]

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The silence of opioids-dependent chronic pain patients: A text mining analysis from sex and gender perspective.

Existing evidence indicates sex-related differences in Prescription Opioid Use Disorder (OUD) in Chronic Non-Cancer Pain (CNCP). However to date, there is scant evidence for other socioeconomic factors in these differences. […]

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