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Dextrose Prolotherapy’s Impact on the Urinary Microbiome in Interstitial Cystitis/Bladder Pain Syndrome.

: Interstitial cystitis/bladder pain syndrome (IC/BPS) is a debilitating chronic condition affecting millions globally. Dextrose prolotherapy, a minimally invasive and safe treatment, has emerged as a potential way to promote […]

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Electroacupuncture Alleviates Neuropathic Pain and Negative Emotion in Mice by Regulating Gut Microbiota [Letter].

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Neurophysiological approaches for managing pain in multiple sclerosis: a mini review.

Chronic pain is a prevalent yet often under-recognized symptom among individuals with multiple sclerosis (MS), affecting 29-86% of the population. This condition can significantly impact the individuals’ functionality, including their […]

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Selective RNAi silencing of Schwann cell Piezo1 alleviates mechanical hypersensitization following peripheral nerve injury.

The present study was designed to investigate the role of Schwann cell (SC) Piezo1 in peripheral nociception. We first developed an AAV vector that has primary SC tropism after delivery […]

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Web Exclusive. Annals Video Summary – Pharmacologic Treatment of Acute Episodic Migraine Headache.

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Extracranial arteriovenous malformations: towards etiology-based therapeutic management.

Anomalies during angiogenesis can initiate the formation of arteriovenous malformations (AVMs), characterized by aberrant connections between arteries and veins and fast lesional blood flow. These anomalies can manifest anywhere in […]

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Elucidating interplay between myrcene and cannabinoid receptor 1 receptors to produce antinociception in mouse models of neuropathic pain.

The need for nonaddictive and effective treatments for chronic pain are at an all-time high. Historical precedence, and now clinical evidence, supports the use of cannabis for alleviating chronic pain. […]

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Potential Role of Menstrual Fluid-Derived Small Extracellular Vesicle Proteins in Endometriosis Pathogenesiss.

Endometriosis, a chronic debilitating disease affects 1 in 7-10 girls and women, who have symptoms of severe chronic pain and subfertility and significantly impacts the overall quality of life. Currently, […]

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Self-suppressing behavioral patterns and depressive traits exacerbate chronic pain: Psychological trait assessment using the structured association technique method.

This study investigated the relationship between psychological traits and chronic pain using the Structured Association Technique (SAT) method to evaluate psychological factors associated with chronic pain. The participants included 105 […]

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Proposition of Two Subtypes of Patients at Risk of Suicide: Pain Hypersensitive Vs. Dissociative.

The pain-suicide relationship is one of the most debated in recent literature, but theories and clinical evidence have often reached contrasting conclusions. Through a critical overview of theoretical, meta-analytical and […]

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