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Early life stress modulates neonatal somatosensation and the transcriptional profile of immature sensory neurons.

Early life stress (ELS) is associated with an increased risk of experiencing chronic pain during adulthood, but surprisingly little is known about the short-term influence of ELS on nociceptive processing […]

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Care trajectories for musculoskeletal disorders following a new episode of low back pain.

This study explored diverse care trajectories (CTs) for low back pain (LBP) and other musculoskeletal disorders (MSDs), over a 5-year period following a first episode of LBP. Based on Quebec’s […]

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Distinct Brain Connectivity Patterns in Sickle Cell Disease: A Biomarker for Chronic Pain Severity.

Central nervous system complications are common in sickle cell disease (SCD), and the defining associated biomarkers are becoming increasingly relevant for physicians in diagnostic and prognostic contexts. Recent studies have […]

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Ditans and Gepants: hope or false promise for menstrual migraine?

Menstrual migraine (MM) is a debilitating migraine subtype associated with hormonal fluctuations, often resistant to conventional treatments. Gepants, novel calcitonin generelated peptide (CGRP) receptor antagonists, and ditans, serotonin 5-HT1F receptor […]

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Trends in Mixed Pain Research Over Three Decades (1993-2024): A Bibliometric Analysis.

The term “mixed pain” is frequently used in clinical practice to describe the coexistence of nociceptive, neuropathic, and nociplastic pain mechanisms. However, its inconsistent use and lack of a formal […]

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Are people with chronic pain more diverse than we think? An investigation of ergodicity.

This study investigates whether data from people with endometriosis (n = 58) and fibromyalgia (n = 58) exhibit what is called “ergodicity,” meaning that results from analyses of aggregated group […]

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Pain distribution can be determined by classical conditioning.

Chronic widespread pain (CWP)-as in many other clinical presentations-manifests in ongoing pain without identifiable structural cause, with pain that spreads over multiple body areas. The development and maintenance of symptoms […]

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Reversal of allodynia and enhanced tendon repair in rats via 660 and 808 nm photobiomodulation.

Our study aimed to explore the potential of Photobiomodulation (PBM) as a treatment for Tendinopathy (TP), a chronic condition characterized by tendon degeneration, inflammation, and pain, for which current treatment […]

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The cortical spreading depression/migraine aura hypothesis – Finally some definitive evidence.

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From adolescence to adulthood: The role of dietary quality in headache and temporomandibular disorder risks.

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