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Differential pain perception among females with or without nonspecific chronic low back pain and comorbid insomnia: a quantitative sensory testing analysis.

Sleep disturbance is a prevalent condition in individuals with chronic low back pain (CLBP). Despite a strong association between the 2 conditions, the potential mechanisms underlying the role of sleep […]

Spontaneous pain dynamics characterized by stochasticity in neural recordings of awake humans with chronic pain.

Chronic pain is characterized by spontaneous fluctuations in pain intensity, a phenomenon that remains poorly understood. The aim of this study is to elucidate the neural mechanisms underlying pain fluctuations […]

IUPHAR Article: Psilocybin induces long-lasting effects via 5-HT receptors in mouse models of chronic pain.

Chronic pain is a debilitating disease with current treatments lacking efficacy and safety, therefore discovery of new treatments is crucial. Initial studies suggest that psychedelics may be feasible for targeting […]

Editorial: Pain and relationships.

Sema3A relieves Neuropathic Pain by Reducing eIF2α Phosphorylation via Suppressing PI3K/Akt/mTOR Pathway.

Primary sensory neurons serve as a critical link between the peripheral nervous system (PNS) and the central nervous system (CNS). They represent the initial neural tissue responsible for transmitting sensations […]

Single-cell RNA sequencing-guided engineering of mitochondrial therapies for intervertebral disc degeneration by regulating mtDNA/SPARC-STING signaling.

Intervertebral disc degeneration (IVDD) is a leading cause of discogenic low back pain, contributing significantly to global disability and economic burden. Current treatments provide only short-term pain relief without addressing […]

Gender Discrimination is Associated with Greater Chronic Pain Interference Among Women.

Pain disparities between men and women are found in multiple domains; women have been shown to experience greater pain intensity, pain disability, and risk for chronic pain. While often ascribed […]

The role of androgens on experimental pain sensitivity: a systemic review and meta-analysis.

Animal studies have shown androgens, especially testosterone, may have an analgesic effect on nociceptive behavior. However, it is unclear if this effect is present in humans. This review and meta-analysis […]

Plasma metabolites associated with endometriosis in adolescents and young adults.

What are the plasma metabolomics profiles associated with endometriosis in adolescents and young adults?

Partner responses to pain among male partners of women with provoked vestibulodynia-a cross-sectional study.

Provoked vestibulodynia (PVD) is a prevalent persistent pain disorder, localized to the vulva, not only affecting the sexual health of women suffering from it but also of their partners. Partner’s […]

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