Accepted

Chronic pain is a debilitating disease with current treatments lacking efficacy and safety, therefore discovery of new treatments is crucial. Initial studies suggest that psychedelics may be feasible for targeting […]

Primary sensory neurons serve as a critical link between the peripheral nervous system (PNS) and the central nervous system (CNS). They represent the initial neural tissue responsible for transmitting sensations […]

Intervertebral disc degeneration (IVDD) is a leading cause of discogenic low back pain, contributing significantly to global disability and economic burden. Current treatments provide only short-term pain relief without addressing […]

Pain disparities between men and women are found in multiple domains; women have been shown to experience greater pain intensity, pain disability, and risk for chronic pain. While often ascribed […]

Animal studies have shown androgens, especially testosterone, may have an analgesic effect on nociceptive behavior. However, it is unclear if this effect is present in humans. This review and meta-analysis […]

What are the plasma metabolomics profiles associated with endometriosis in adolescents and young adults?

Provoked vestibulodynia (PVD) is a prevalent persistent pain disorder, localized to the vulva, not only affecting the sexual health of women suffering from it but also of their partners. Partner’s […]

In the peripheral nervous system, nociceptors become hyperexcitable in both acute and chronic pain conditions. This phenotype can be mediated by dysregulated calcium, which occurs if the endoplasmic reticulum (ER) […]

In the context of vulvodynia, a gynecological disorder characterized by chronic vulvar pain affecting an estimated 10% of women, with significant impacts on sexual health, mental well-being, and productivity, the […]