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rTMS and TENS Relieve Neuropathic Pain in CCI Model Rats by Modulating Central Nervous System TRPV1 and Neuroinflammation.

Repetitive transcranial magnetic stimulation (rTMS) of the prefrontal cortex (PFC) and transcutaneous electrical nerve stimulation (TENS) have both been demonstrated as effective at alleviating neuropathic pain (NP). However, the comparative […]

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Protective role of TRPV1 nociceptive neurons communication to macrophages against T. cruzi infection in mice.

Chagas’ disease is a life-threatening condition caused by T. cruzi. Patients with chronic disease may develop gastrointestinal, neurological, or associated neuro-digestive dysfunctions. CNS invasion by can occur in the acute […]

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Phenome-wide diagnostic comparison among suicide deaths and living individuals with chronic pain diagnoses.

Chronic pain, regardless of its type, is a significant risk factor for suicide. However, not all individuals with chronic pain also experience suicidal thoughts and behaviors. Better characterization of clinical […]

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Investigating pain-related medication use and contribution to polypharmacy in adults with intellectual disabilities: a systematic review.

Adults with intellectual disability experience more pain than adults without and, despite a higher number of medications being prescribed, may be less likely to receive medication for pain. We conducted […]

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Alterations of white matter microstructure in migraine patients vary in the peri-ictal phases.

Alterations in white matter (WM) microstructure are commonly found in migraine patients. Here, we employ a longitudinal study of episodic migraine without aura using diffusion MRI (dMRI) to investigate whether […]

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Development of a remote therapeutic monitoring platform: applications for movement disorders.

Digital health tools are emerging as a promising solution for optimizing Deep Brain Stimulation (DBS) therapy for neurodegenerative diseases such as Parkinson’s Disease (PD), addressing challenges of therapy maintenance, care […]

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Electroencephalographic power ratio and peak frequency difference associate with central sensitization in chronic pain.

Central sensitization, or increased responsiveness of the central nervous system to sensory input, is present in many chronic pain patients. Clinically, it is detected through subjective, patient-reported measures. There is […]

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Peroxisome proliferator-activated receptor gamma: A promising therapeutic target for the treatment of chronic pain.

Chronic pain represents an incapacitating medical condition that profoundly impacts the patients’ quality of life. Managing chronic pain poses a significant challenge for healthcare professionals due to its multifaceted nature […]

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Novel Benzimidazole Derivatives as Potent Inhibitors of Microsomal Prostaglandin E Synthase 1 for the Potential Treatment of Inflammation, Pain, and Fever.

Microsomal prostaglandin E synthase 1 (mPGES-1) is a promising target for treating inflammatory diseases and pain. This study introduces a novel series of benzimidazoles, with the most potent analogs exhibiting […]

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SPECIALIZED PRO-RESOLVING MEDIATOR MARESIN 1 ATTENUATES PAIN IN A MOUSE MODEL OF OSTEOARTHRITIS.

We test whether the specialized pro-resolving molecule Maresin 1 (MaR1) attenuates nociceptive behaviors in mice with osteoarthritis-like pain.

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