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Alpha-bisabolol and camphene have demonstrated analgesic effects in inflammatory pain models by blocking Cav3.2 calcium channels. As the pain pathway overlaps with mechanisms for itch, and because Cav3.2 channels have […]
Learn More >Rheumatoid arthritis (RA) is a prevalent autoimmune disorder marked by chronic inflammatory arthritis and systemic effects. The etiology of RA is complex, involving genetic factors like HLA-DR4 and HLA-DR1, as […]
Learn More >Spinal cord stimulation (SCS) is a well-accepted therapy for refractory chronic pain. However, predicting responders remain a challenge due to a lack of objective pain biomarkers. The present study applies […]
Learn More >The lateral parabrachial nucleus (LPBn) serves a critical hub for processing and transmitting pain signals. It has two main efferent pathways, the LPBn-CeA and LPBn-BNST, which are crucial for pain […]
Learn More >The purpose of this study was to evaluate the participation of spinal peroxisome proliferator-activated receptor gamma (PPARγ) in the antiallodynic effect of cannabidiol, the expression of PPARγ in sites relevant […]
Learn More >Persistent nociceptive inputs arising from peripheral tissues or/and nerve injuries cause maladaptive changes in neurons or neural circuits in the central nervous system, which further confer acute injury into chronic […]
Learn More >Neuropathic pain constitutes a clinical problem more prevalent among women. In this issue of Neuron, Fan et al. identify distinct sex-dependent pathways driving nociception. Importantly, T cells release the adipokine leptin in […]
Learn More >The 11th revision of the International Classification of Diseases (ICD-11) now includes separate chronic pain diagnoses that may be extended by chronic pain severity specifiers. These specifiers comprise 3 dimensions-pain […]
Learn More >Sleep disturbance is a prevalent condition in individuals with chronic low back pain (CLBP). Despite a strong association between the 2 conditions, the potential mechanisms underlying the role of sleep […]
Learn More >Chronic pain is characterized by spontaneous fluctuations in pain intensity, a phenomenon that remains poorly understood. The aim of this study is to elucidate the neural mechanisms underlying pain fluctuations […]
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