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Validation of ICD-11 chronic pain severity specifiers for children and adolescents: an important step forward.

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Formation of perineuronal nets within a thalamocortical circuit shapes mechanical and thermal pain thresholds in mice with neuropathic pain.

We moved from the hypothesis that perineuronal nets (PNNs), which are condensed structures of the extracellular matrix surrounding GABAergic interneurons in the forebrain, contribute to mechanisms of maladaptive neuronal plasticity […]

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Clinical characteristics, comorbidities, and correlation with advanced lipedema stages: A retrospective study from a Swiss referral centre.

Lipedema is a chronic condition involving abnormal fat deposition in the lower limbs, often underdiagnosed, and poorly understood. We examined the epidemiological and clinical characteristics of a large patient cohort […]

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Provider Perceptions of Burden in Patients with Chronic Pain: Implications for Disparities in Healthcare Delivery.

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Implementation-effectiveness of the power over pain portal for patients awaiting a tertiary care consultation for chronic pain: A pilot feasibility study.

The Power Over Pain (POP) Portal is a digital platform that provides people living with pain (PLWP) flexible access to chronic pain self-management resources.

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Sex-based differences in biomechanical function for chronic low back pain and how it relates to pain experience.

The relationship between pain experience and biomechanical impairment in chronic low back pain (LBP) is unclear. Among the broader pain literature, sex-based differences in pain experience have been established. However, […]

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Development of the barriers to opioid access scale among individuals with chronic pain.

Measurement of accessibility is a crucial pillar in assessing equity of access to pain treatment, particularly in the context of reducing opioid prescribing in response to rising overdose deaths in […]

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Lead-Free Halide Perovskite-Based Flexible Memristor for an Artificial Mechano-nociceptive System.

Herein, novel lead-free CsBiI nanocrystals (NCs) were preferred through first-principles calculations and crystal orbital Hamilton population (COHP). An artificial nociceptor was designed using the lead-free halide perovskite (HP) CsBiI NCs […]

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The Mitochondrial Targeting Drug SkQ1 Attenuates the Progression of Post- Traumatic Osteoarthritis through Suppression of Mitochondrial Oxidative Stress.

Background Post-traumatic osteoarthritis (PTOA) constitutes a distinct subtype of osteoarthritis (OA). Despite extensive research, no effective pharmacological intervention has been established to prevent or halt the progression of PTOA. Current […]

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Mitochondrial dysfunction in trigeminal ganglion contribute to nociceptive behavior in a nitroglycerin-induced migraine mouse model.

Migraine is a chronic episodic neurological disorder. However, its diagnosis and management remain unclear. The pathogenesis of migraine is intricately linked to the dysfunction of mitochondria, and aberrant trigeminal neuronal […]

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