Accepted

Background Post-traumatic osteoarthritis (PTOA) constitutes a distinct subtype of osteoarthritis (OA). Despite extensive research, no effective pharmacological intervention has been established to prevent or halt the progression of PTOA. Current […]

Migraine is a chronic episodic neurological disorder. However, its diagnosis and management remain unclear. The pathogenesis of migraine is intricately linked to the dysfunction of mitochondria, and aberrant trigeminal neuronal […]

Alpha-bisabolol and camphene have demonstrated analgesic effects in inflammatory pain models by blocking Cav3.2 calcium channels. As the pain pathway overlaps with mechanisms for itch, and because Cav3.2 channels have […]

Rheumatoid arthritis (RA) is a prevalent autoimmune disorder marked by chronic inflammatory arthritis and systemic effects. The etiology of RA is complex, involving genetic factors like HLA-DR4 and HLA-DR1, as […]

Spinal cord stimulation (SCS) is a well-accepted therapy for refractory chronic pain. However, predicting responders remain a challenge due to a lack of objective pain biomarkers. The present study applies […]

The lateral parabrachial nucleus (LPBn) serves a critical hub for processing and transmitting pain signals. It has two main efferent pathways, the LPBn-CeA and LPBn-BNST, which are crucial for pain […]

The purpose of this study was to evaluate the participation of spinal peroxisome proliferator-activated receptor gamma (PPARγ) in the antiallodynic effect of cannabidiol, the expression of PPARγ in sites relevant […]

Persistent nociceptive inputs arising from peripheral tissues or/and nerve injuries cause maladaptive changes in neurons or neural circuits in the central nervous system, which further confer acute injury into chronic […]

Neuropathic pain constitutes a clinical problem more prevalent among women. In this issue of Neuron, Fan et al. identify distinct sex-dependent pathways driving nociception. Importantly, T cells release the adipokine leptin in […]

The 11th revision of the International Classification of Diseases (ICD-11) now includes separate chronic pain diagnoses that may be extended by chronic pain severity specifiers. These specifiers comprise 3 dimensions-pain […]