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EXPRESS: Unraveling the Role of Gut Microbiota and Plasma Metabolites in Fibromyalgia: Insights from Mendelian Randomization and Dietary Interventions.

Fibromyalgia (FM) is a complex disorder characterized by chronic pain, fatigue, and functional impairments, with unclear pathological mechanisms. Gut microbiota and plasma metabolites have been implicated in FM, but their […]

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Two-Phase Inpatient Withdrawal Programme for Long-Term Opioid Use in Non-Cancer Pain.

High-dose long-term opioid treatment for chronic non-cancer pain (CNCP) has become an increasing burden in industrialised countries. Opioid tapering and withdrawal in patients with CNCP remain challenging. This study evaluated […]

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Attachment in Young Adults With Chronic Pain: The Mediating Role of Cognitive Appraisals in the Relationship Between Attachment Security, Pain Coping and Functioning.

Attachment styles can influence how individuals perceive and cope with chronic pain. This study examined the relationships between attachment security, pain coping and functioning in young adults with chronic pain, […]

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Neuropathic pain appears to be the main symptom associated with higher disease burden and lower pain alleviation in degenerative lumbar disease fusion patients.

The role of neuropathic pain (NP) in persisting pain after degenerative lumbar disease (DLD) fusion surgery appears to be underrecognized and undertreated.

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Uncovering the Hidden Link Between the Aberrant Intestinal Microbiome and Fibromyalgia.

Fibromyalgia is a multifaceted syndrome primarily characterized by chronic widespread pain and fatigue. Despite its significant prevalence and incidence, the mechanisms mediating the disease pathogenesis have remained poorly understood; however, […]

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The advancement and utility of multimodal imaging in the diagnosis of degenerative disc disease.

Degenerative disc disease (DDD) is a common spinal condition characterized by the deterioration of intervertebral discs, leading to chronic back pain and reduced mobility. While magnetic resonance imaging (MRI) has […]

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Histone deacetylases: the critical enzymes for microglial activation involved in neuropathic pain.

Neuropathic pain is a common health problem in clinical practice that can be caused by many different factors, including infection, ischemia, trauma, diabetes mellitus, nerve compression, autoimmune disorders, cancer, trigeminal […]

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Accelerated intermittent theta burst transcranial magnetic stimulation of the dorsolateral prefrontal cortex for chronic knee osteoarthritis pain.

This study assessed feasibility, safety, and tolerability of accelerated intermittent theta burst stimulation (aiTBS) with effective connectivity-guidance targeting the left dorsolateral prefrontal cortex (lDLPFC) from the right anterior insular (rAI) […]

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Self-reported questionnaires assessing body perception disturbances in adults with chronic non-cancer pain: a scoping review.

Body perception disturbances (BPD) are well documented in certain chronic pain populations [e.g., complex regional pain syndrome (CRPS)], while being far less studied in chronic pain as a general condition. […]

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Serum neurofilament light chain and structural and Functional nerve fiber loss in painful and painless diabetic polyneuropathy.

To explore associations between the axonal protein Neurofilament Light (NfL) and severity of Diabetic Polyneuropathy (DPN) and pain.

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