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Multidimensional pain assessment and opioid use after total knee arthroplasty: continuous vs single-injection regional vs systemic analgesia.

Effective pain management after total knee arthroplasty (TKA) is essential for recovery. Continuous peripheral nerve blocks (PNBc) are often believed to provide superior pain relief compared with single-injection peripheral nerve […]

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The structural diversity of psychedelic drug actions revealed.

There is currently a resurgence in exploring the utility of classical psychedelics to treat depression, addiction, anxiety disorders, cluster headaches, and many other neuropsychiatric disorders. A biological target of these […]

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Validation of ICD-11 chronic pain severity specifiers for children and adolescents: an important step forward.

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Formation of perineuronal nets within a thalamocortical circuit shapes mechanical and thermal pain thresholds in mice with neuropathic pain.

We moved from the hypothesis that perineuronal nets (PNNs), which are condensed structures of the extracellular matrix surrounding GABAergic interneurons in the forebrain, contribute to mechanisms of maladaptive neuronal plasticity […]

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Clinical characteristics, comorbidities, and correlation with advanced lipedema stages: A retrospective study from a Swiss referral centre.

Lipedema is a chronic condition involving abnormal fat deposition in the lower limbs, often underdiagnosed, and poorly understood. We examined the epidemiological and clinical characteristics of a large patient cohort […]

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Provider Perceptions of Burden in Patients with Chronic Pain: Implications for Disparities in Healthcare Delivery.

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Implementation-effectiveness of the power over pain portal for patients awaiting a tertiary care consultation for chronic pain: A pilot feasibility study.

The Power Over Pain (POP) Portal is a digital platform that provides people living with pain (PLWP) flexible access to chronic pain self-management resources.

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Sex-based differences in biomechanical function for chronic low back pain and how it relates to pain experience.

The relationship between pain experience and biomechanical impairment in chronic low back pain (LBP) is unclear. Among the broader pain literature, sex-based differences in pain experience have been established. However, […]

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Development of the barriers to opioid access scale among individuals with chronic pain.

Measurement of accessibility is a crucial pillar in assessing equity of access to pain treatment, particularly in the context of reducing opioid prescribing in response to rising overdose deaths in […]

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Lead-Free Halide Perovskite-Based Flexible Memristor for an Artificial Mechano-nociceptive System.

Herein, novel lead-free CsBiI nanocrystals (NCs) were preferred through first-principles calculations and crystal orbital Hamilton population (COHP). An artificial nociceptor was designed using the lead-free halide perovskite (HP) CsBiI NCs […]

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