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Brief interventions for chronic pain: Approaches and evidence.

Various countries have published national guidance supporting the integration of behavioral approaches into chronic pain treatment. Yet multiple barriers prevent broad patient access. Brief treatment formats may address universal shortcomings […]

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Matched serum- and urine-derived biomarkers of interstitial cystitis/bladder pain syndrome.

Setting up the correct diagnosis of interstitial cystitis/bladder pain syndrome (IC/BPS), a chronic inflammatory disease of the bladder, is a challenge, as there are neither diagnostic criteria nor reliable and […]

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Healthy core: Harmonizing brain MRI for supporting multicenter migraine classification studies.

Multicenter and multi-scanner imaging studies may be necessary to ensure sufficiently large sample sizes for developing accurate predictive models. However, multicenter studies, incorporating varying research participant characteristics, MRI scanners, and […]

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AIM2 promotes excitatory glutamate receptor expression by inhibiting STING and contributes to bone cancer pain in male mice.

Bone cancer pain (BCP) is a common clinical problem in cancer patients. The plasticity of excitatory neurons within the spinal dorsal horn plays a significant role in the development of […]

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Engineering spatially-confined conduits to tune nerve self-organization and allodynic responses via YAP-mediated mechanotransduction.

Chronic allodynia stemming from peripheral stump neuromas can persist for extended periods, significantly compromising patients’ quality of life. Conventional managements for nerve stumps have demonstrated limited effectiveness in ensuring their […]

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PEGylated Platinum Nanoparticles: A Comprehensive Study of Their Analgesic and Anti-Inflammatory Effects.

Pain and inflammation are common symptoms of a majority of the diseases. Chronic pain and inflammation, as well as related dreadful disorders, remain difficult to control due to a lack […]

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Immune-inflammatory effects of the multicomponent intervention FIBROWALK in outdoor and online formats for patients with fibromyalgia.

The multicomponent intervention FIBROWALK integrates pain science education (PSE), therapeutic exercise, cognitive behavioral therapy (CBT), and mindfulness training for treating fibromyalgia (FM). This study investigated the effects of the FIBROWALK […]

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Seeing your child in pain: Parent empathy in the context of their child’s chronic pain.

Observing your child in pain is inherently distressing. In the context of chronic pain, caregiver responses can powerfully impact child pain-related functioning. The Parent Empathy in the Context of Pain […]

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Epigenetics as the molecular substrate of multimodal lifestyle approaches for patients with persistent pain.

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Thalamo-Insular cortex connections in the Rat and Human.

The insular cortex (ICx) has a role in large a variety of functions. Thalamus plays an important role in modulating cortical functions. The present study aims to show thalamic-ICx connections […]

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