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The advancement and utility of multimodal imaging in the diagnosis of degenerative disc disease.

Degenerative disc disease (DDD) is a common spinal condition characterized by the deterioration of intervertebral discs, leading to chronic back pain and reduced mobility. While magnetic resonance imaging (MRI) has […]

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Histone deacetylases: the critical enzymes for microglial activation involved in neuropathic pain.

Neuropathic pain is a common health problem in clinical practice that can be caused by many different factors, including infection, ischemia, trauma, diabetes mellitus, nerve compression, autoimmune disorders, cancer, trigeminal […]

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Accelerated intermittent theta burst transcranial magnetic stimulation of the dorsolateral prefrontal cortex for chronic knee osteoarthritis pain.

This study assessed feasibility, safety, and tolerability of accelerated intermittent theta burst stimulation (aiTBS) with effective connectivity-guidance targeting the left dorsolateral prefrontal cortex (lDLPFC) from the right anterior insular (rAI) […]

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Self-reported questionnaires assessing body perception disturbances in adults with chronic non-cancer pain: a scoping review.

Body perception disturbances (BPD) are well documented in certain chronic pain populations [e.g., complex regional pain syndrome (CRPS)], while being far less studied in chronic pain as a general condition. […]

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Serum neurofilament light chain and structural and Functional nerve fiber loss in painful and painless diabetic polyneuropathy.

To explore associations between the axonal protein Neurofilament Light (NfL) and severity of Diabetic Polyneuropathy (DPN) and pain.

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Amniotic fluid stem cell conditioned medium’s role in Schwann cell proliferation, survival, and cellular antioxidant activity under normative and oxidative stress conditions.

Peripheral nerve injuries present a major clinical challenge due to their high morbidity and often incomplete recovery of function. While autografts remain the gold standard for nerve repair, their use […]

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Effect of Physical Activity on Chronic Widespread Pain: Insights From Meta-Analysis and Two-Sample Mendelian Randomization.

Chronic widespread pain (CWP) is a core symptom of fibromyalgia that is associated with significant morbidity and mortality. Despite the widespread recommendation for physical activity (PA) in management, the heterogeneity […]

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Application of a Nociceptive Test Battery to Assess Potential Synergy between Two Analgesics in Healthy Subjects.

Chronic pain management remains a major challenge due to the risks associated with conventional treatments, such as opioids and NSAIDs, which carry significant risks, including addiction, tolerance, and adverse side […]

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Synthesis and Biological Evaluation of Metamorphine: A Morphine-Metamizole Adduct from Patient-Controlled Analgesia Pumps.

Opioids are among the most effective drugs in managing moderate to severe pain. Herein, we describe a morphine-metamizole adduct with a phenazone moiety added at position C2 of the morphinan […]

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Risk factors associated with the development and persistence of pain in adolescents: an international Delphi study.

Despite significant advancements in research on paediatric pain, a consensus on the primary risk factors (RFs) for the development and persistence of pain in this population has not yet been […]

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