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As different as fear and anxiety: Introducing the fear and anxiety model of placebo hypoalgesia and nocebo hyperalgesia.

Research suggests that negative affective states, such as fear and anxiety that accompany placebo treatment may be considered predictors of placebo hypoalgesia and nocebo hyperalgesia. There is also data showing […]

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Consumer perspectives of the group itself in group-delivered programs for people with chronic pain: a systematic review and meta-synthesis.

Group-delivered programs for chronic pain are evidence-based and frequently used. The contribution of group factors to outcomes is unclear and there are no integrated findings on consumer perceptions of the […]

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Klotho mutation does not accelerate intervertebral disc aging in mice.

Aging is a risk factor for several chronic conditions, including intervertebral disc degeneration and associated back pain. Disc pathologies include loss of reticular-shaped nucleus pulposus cells, disorganization of annulus fibrosus […]

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Refining Chronic Pain Phenotypes: A Comparative Analysis of Sociodemographic and Disease-Related Determinants Using Electronic Health Records.

The use of electronic health records (EHR) for chronic pain phenotyping has gained significant attention in recent years, with various algorithms being developed to enhance accuracy. Structured data fields (e.g., […]

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Exploring Chronic Pain in Hemodialysis Patients: An Observational Study Based on the New IASP Classification for ICD-11.

Pain is one of the most frequently reported symptoms in hemodialyzed (HD) patients, with prevalence rates between 33% and 82%. Risk factors for chronic pain in HD patients are older […]

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Prevalence of anhedonia in women with deep endometriosis.

Anhedonia, characterized by diminished motivation and pleasure sensitivity, is increasingly recognized as prevalent among patients with chronic pain. Deep Endometriosis (DE), the most severe endophenotype of the disease, is commonly […]

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Surgical frequency analysis of patients clustered according to postoperative pain trajectory: a retrospective study.

Oropharyngeal and orthognathic surgeries cause more postoperative pain than simple dental procedures. The lack of detailed pain pattern analysis after dental surgeries makes pain management challenging. We assessed postoperative pain […]

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Difficult Chronic Pain Clinical Encounters Are Common and Not Easy for the Clinician.

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Sleep deprivation affects pain sensitivity by increasing oxidative stress and apoptosis in the medial prefrontal cortex of rats via the HDAC2-NRF2 pathway.

Sleep is crucial for sustaining normal physiological functions, and sleep deprivation has been associated with increased pain sensitivity. The histone deacetylases (HDACs) are known to significantly regulate in regulating neuropathic […]

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Efficacy and Safety of SHR8554 on Postoperative Pain in Subjects with Moderate to Severe Acute Pain Following Orthopedic Surgery: A Multicenter, Randomized, Double-blind, Dose-explored, Active-controlled, Phase II/III Clinical Trial.

Biased µ-opioid receptor (MOR) agonists enhance pain relief by selectively activating G protein-coupled receptor signaling and minimizing β-arrestin-2 activation, resulting in fewer side effects. This multicenter Phase II/III trial evaluated […]

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