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High-resolution whole-genome DNA methylation revealed unique signatures of painful diabetic neuropathy.

The aim of this work was to describe the DNA methylation signature and to identify genes associated with neuropathic pain in type 2 diabetes mellitus. We analyzed two independent diabetic […]

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Analysis of the relationships between the degree of migraine with right-to-left shunts and changes in white matter lesions and brain structural volume.

To investigate the location of white matter lesions (WMLs) in migraineurs with right‒to‒left shunts (RLS); the relationships among the severity of WMLs, changes in brain structural volume and RLS shunts; […]

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Brainstem serotonin amplifies nociceptive transmission in a mouse model of Parkinson’s disease.

Parkinson’s disease arises from the degeneration of dopaminergic neurons in the substantia nigra pars compacta, leading to motor symptoms such as akinesia, rigidity, and tremor at rest. The non-motor component […]

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Evaluating factors impacting National Institutes of Health funding in pain medicine.

While many medical specialties have established links between bibliometric indices, academic rank, leadership roles, and National Institutes of Health (NIH) funding, there exists a gap within the field of pain […]

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Inactivation of ATG13 stimulates chronic demyelinating pathologies in muscle-serving nerves and spinal cord.

Chronic muscle fatigue is a condition characterized by debilitating muscle weakness and pain. Based on our recent finding to study the potential effect of mTOR on ATG13 inactivation in chronic […]

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Dialysis Headache: An Updated Literature Review.

The objective of this review is to describe recent updates in the understanding of dialysis headache. These recent findings will be placed in a historical context that reviews the clinical […]

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Research progress in neuropathic pain after spinal cord injury: a bibliometric study from 2013 to 2024.

The incidence of neuropathic pain (NP) after spinal cord injury (SCI) is quite high. This pain is clinically challenging to treat and has an debilitating effect on patients. In recent […]

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Novel sigma 1-antagonists with -(+)-normetazocine scaffold: synthesis, molecular modeling, and antinociceptive effect.

Inflammatory pain represents one of the unmet clinical needs for patients, as conventional therapies cause several side effects. Recently, new targets involved in inflammatory pain modulation have been identified, including […]

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A novel SIRT1 activator attenuates neuropathic pain by inhibiting spinal neuronal activation via the SIRT1-mGluR1/5 pathway.

Neuropathic pain is a type of pain caused by an injury or disease of the somatosensory nervous system. Currently, there is still absence of effective therapeutic drugs for neuropathic pain, […]

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Impact of different treatments for chronic pain on cognitive function: A systematic review.

Experimental evidence supports the hypothesis of reciprocal influence between neural systems involved in cognition and central pain processing circuits. Furthermore, studies have demonstrated bidirectional communication between central pain processing areas […]

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