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Tolerability issues including acne, nausea, and headache have been reported with Janus kinase (JAK) inhibitors for moderate-to-severe atopic dermatitis (AD). To report outcomes of tolerability adverse events (AEs) for baricitinib, […]
Learn More >Rheumatoid arthritis (RA), a chronic autoimmune disease, is characterized by articular pain and swelling, synovial hyperplasia, and cartilage and bone destruction. Conventional treatment strategies for RA involve the use of […]
Learn More >Pain in rheumatoid arthritis (RA) is considered to be associated with non-inflammatory factors, including physical disabilities, psychiatric disorders, and pain catastrophizing (PC). PC is reportedly a key driver in the […]
Learn More >Opioid analgesic tolerance, a root cause of opioid overdose and misuse, can develop through an associative learning. Despite intensive research, the locus and central pathway subserving the associative opioid analgesic […]
Learn More >Neuropathic pain is associated with nervous system injury and the production of pro‑inflammatory factors. Critical functions for ubiquitin‑specific peptidase 53 (USP53) have been demonstrated in various diseases. However, the role […]
Learn More >Organisms rely on chemical cues in their environment to indicate the presence or absence of food, reproductive partners, predators or other harmful stimuli. In the nematode Caenorhabditis elegans, the bilaterally […]
Learn More >The onset of the coronavirus disease 2019 (COVID-19) necessitated a rapid transition to virtual care for chronic pain treatment.
Learn More >The microtubule-stabilizing drug paclitaxel (PTX) is an important chemotherapeutic agent for cancer treatment and causes peripheral neuropathy as a common side effect that substantially impacts the functional status and quality […]
Learn More >To evaluate mental health burden in women with idiopathic intracranial hypertension (IIH) compared to matched women with migraine and population controls.
Learn More >Nociplastic pain is a severe health problem, while its mechanisms are still unclear. (R, S)-3,5-Dihydroxyphenylglycine (DHPG) is a group I metabotropic glutamate receptor (mGluR) agonist that can cause central sensitization, […]
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