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Global burden of neck pain and its gender and regional inequalities from 1990 – 2021: a comprehensive analysis from the Global Burden of Disease Study 2021.

Neck pain is a growing public health concern, no recent research has comprehensively examined its incidence and years lived with disability (YLDs) across different regions and genders. For the first […]

Nociceptor-localized KCC2 suppresses brachial plexus avulsion-induced neuropathic pain and related central sensitization.

Lack in understanding of the mechanism on brachial plexus avulsion (BPA)-induced neuropathic pain (NP) is the key factor restricting its treatment. In the current investigation, we focused on the nociceptor-localized […]

Biosynthesis inhibition of miR-142-5p in a N-methyladenosine-dependent manner induces neuropathic pain through CDK5/TRPV1 signaling.

Neuropathic pain (NP) represents a debilitating and refractory condition. However, the understanding of NP and the current treatment approaches available for its management are limited. Therefore, there is a significant […]

Fitness-to-work considerations in the paradigmatic pain condition of headache disorder.

Headache disorders are common, including in the working population. Clinicians caring for patients with headache need to be aware of work-related factors as potential causes or triggers of headache disorders, […]

The Mechanism of Acupuncture Therapy for Migraine: A Systematic Review of Animal Studies on Rats.

Acupuncture has long been used for migraine treatment as it is convenient for use and has remarkable efficacy. The acupuncture-based comprehensive treatment plan has been widely recognized for migraine prevention […]

Reliability of nociceptive monitors vs. standard practice during general anesthesia: a prospective observational study.

Inadequate or excessive nociceptive control during general anesthesia can result in significant adverse outcomes. Using traditional clinical variables, such as heart rate, systolic blood pressure, and respiratory rate, to assess […]

Causal Association Between Obstructive Sleep Apnea and Migraine: A Bidirectional Mendelian Randomization Study.

Patients with obstructive sleep apnea (OSA) frequently suffer from migraine, however the causal relationship between OSA and migraine is unknown. Investigating the causation will assist in understanding the etiology of […]

Revisiting substance P in migraine: a methodological approach inspired by anti-CGRP and anti-PACAP success.

Substance P, previously dismissed as a therapeutic target for migraine due to the failure of neurokinin-1 receptor antagonists, warrants renewed attention. Building on the success of therapies targeting the calcitonin […]

Long COVID facts and findings: a large-scale online survey in 74,075 Chinese participants.

Research on long COVID in China is limited, particularly in terms of large-sample epidemiological data and the effects of recent SARS-CoV-2 sub-variants. China provides an ideal study environment owing to […]

Development of the symptomatic dermographism quality of life questionnaire.

Symptomatic Dermographism (SD), also known as “urticaria factitia”, is the most common subtype of chronic inducible urticaria. Affected patients develop itch and strip-shaped wheals that usually last for 30 min after […]

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