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Metformin attenuates symptoms of osteoarthritis: role of genetic diversity of Bcl2 and CXCL16 in OA.

This study aimed to evaluate the effectiveness of metformin versus placebo in overweight patients with knee osteoarthritis (OA). In addition, to assess the effects of inflammatory mediators and apoptotic proteins […]

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Endometriosis leads to central nervous system-wide glial activation in a mouse model of endometriosis.

Chronic pelvic pain (CPP) is a common symptom of endometriosis. Women with endometriosis are also at a high risk of suffering from anxiety, depression, and other psychological disorders. Recent studies […]

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The HARDSHIP databases: a forthcoming free good from the Global Campaign against Headache.

In order to pursue its purpose of reducing the global burden of headache, the Global Campaign against Headache has gathered data on headache-attributed burden from countries worldwide. These data, from […]

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Loss of astrocytic A1 adenosine receptor is involved in a chemotherapeutic agent-induced rodent model of neuropathic pain.

Oxaliplatin is a commonly used platinum chemotherapy drug while peripheral neurotoxicity is a widely observed adverse reaction lacking a satisfactory therapeutic strategy. Different adenosine receptors underlying the common neuropathic phenotype […]

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Effect of peripheral magnetic stimulation on acute and chronic pain after surgery: A systematic review and meta-analysis.

Peripheral magnetic stimulation is a potentially promising modality to help manage postoperative pain. We systematically reviewed the effect of peripheral magnetic stimulation on acute and chronic postoperative pain. MEDLINE, Cochrane […]

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Spinal cord stimulation for low back pain.

Spinal cord stimulation (SCS) is a surgical intervention used to treat persistent low back pain. SCS is thought to modulate pain by sending electrical signals via implanted electrodes into the […]

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A machine learning approach to support triaging of primary versus secondary headache patients using complete blood count.

Headaches account for up to 4.5% of emergency department visits, where they present a significant diagnostic challenge. While primary headaches are benign, secondary headaches can be life-threatening. It is essential […]

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The structure, function, and pharmacology of MRGPRs.

Mas-related G protein-coupled receptor (MRGPR) family members play important roles in the sensation of noxious stimuli and represent novel targets for the treatment of itch and pain. MRGPRs recognize a […]

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Prevalence and correlates of prescription opioid use among US adults, 2019-2020.

This study estimates the prevalence of prescription opioid use (POU) in the United States (US) in 2019-2020, both in the general population and specifically among adults with pain. It also […]

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Maresin1 can be a potential therapeutic target for nerve injury.

Nerve injury significantly affects human motor and sensory function due to destruction of the integrity of nerve structure. In the wake of nerve injury, glial cells are activated, and synaptic […]

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