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Neurons in the caudal ventrolateral medulla mediate descending pain control.

Supraspinal brain regions modify nociceptive signals in response to various stressors including stimuli that elevate pain thresholds. The medulla oblongata has previously been implicated in this type of pain control, […]

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Inhibition of nonsense-mediated decay induces nociceptive sensitization through activation of the integrated stress response.

RNA stability is meticulously controlled. Here, we sought to determine if an essential post-transcriptional regulatory mechanism plays a role in pain. Nonsense-mediated decay (NMD) safeguards against translation of mRNAs that […]

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Associations between chronic pain, anxiety, and depression among adults in the United States.

Determine the associations of depression and anxiety with chronic pain among United States adults.

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Evaluating Osteoarthritis Management Programs: Outcome Domain Recommendations from the OARSI Joint Effort Initiative.

To develop sets of core and optional recommended domains for describing and evaluating Osteoarthritis Management Programs (OAMPs), with a focus on hip and knee OA.

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How to entrain a selected neuronal rhythm but not others: open-loop dithered brain stimulation for selective entrainment.

While brain stimulation therapies such as deep brain stimulation for Parkinson’s disease (PD) can be effective, they have yet to reach their full potential across neurological disorders. Entraining neuronal rhythms […]

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Nerve injury-induced gut dysbiosis contributes to spinal cord TNF-α expression and nociceptive sensitization.

The impact of the gut microbiota on glial cell growth and maturation via the gut-brain axis is highlighted herein. Considering that glial activation is crucial for onset and maintenance of […]

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Activation of the bile acid receptors TGR5 and FXR in the spinal dorsal horn alleviates neuropathic pain.

Beyond digestion, bile acids have been recognized as signaling molecules with broad paracrine and endocrine functions by activating plasma membrane receptor (Takeda G protein-coupled receptor 5, TGR5) and the nuclear […]

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Subgrouping patients with zoster-associated pain according to sensory symptom profiles: A cluster analysis.

Patients with zoster-associated pain exhibit a variety of sensory symptoms and forms of pain and complain of different pain patterns. The purpose of this study is to subgroup patients with […]

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New techniques and methods for prevention and treatment of symptomatic traumatic neuroma: A systematic review.

Generally, axons located at the central end of the nerve system will sprout after injury. Once these sprouts cannot reach the distal end of the severed nerve, they will form […]

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Emerging roles of miRNAs in neuropathic pain: From new findings to novel mechanisms.

Neuropathic pain, which results from damage to the somatosensory nervous system, is a global clinical condition that affects many people. Neuropathic pain imposes significant economic and public health burdens and […]

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