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The mechanistic basis for the effects of electroacupuncture on neuropathic pain within the central nervous system.

Nociceptive signaling responses to painful stimuli are transmitted to the central nervous system (CNS) from the afferent nerves of the periphery through a series of neurotransmitters and associated signaling mechanisms. […]

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Effects of Orthopedic Manual Therapy on Pain Sensitization in Patients with Chronic Musculoskeletal Pain: An Umbrella Review with Meta-Meta-Analysis.

The aim of this umbrella review with meta-meta-analysis was to assess the effectiveness of orthopedic manual therapy in isolation on pain sensitization in patients with chronic musculoskeletal pain.

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Fibromyalgia predicts increased odds of pain-related addiction exacerbation among individuals with pain and opioid use disorder.

Fibromyalgia and opioid use disorder (OUD) are highly impactful chronic illnesses with substantially overlapping psychosocial, biological, and clinical features. Little previous research has examined interactions between fibromyalgia and OUD. Limiting […]

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The Tampa Scale of Kinesiophobia – A systematic review of its psychometric properties in people with musculoskeletal pain.

The aims of this systematic review were to identify the different versions of the TSK and to report on the psychometric evidence relating to these different versions for people suffering […]

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Neurotensin Receptor Allosterism Revealed in Complex with a Biased Allosteric Modulator.

The NTSR1 neurotensin receptor (NTSR1) is a G protein-coupled receptor (GPCR) found in the brain and peripheral tissues with neurotensin (NTS) being its endogenous peptide ligand. In the brain, NTS […]

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Associations Between Shower and Moisturizing Practices with Atopic Dermatitis Severity: A Prospective Longitudinal Cohort Study.

Evidence-based recommendations for optimal showering/bathing practices are lacking for atopic dermatitis (AD) patients. To determine longitudinal associations between showering/bathing practices and AD severity in AD patients. A prospective single-center dermatology […]

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Burden of Disease and Unmet Needs in Atopic Dermatitis: Results From a Patient Survey.

Atopic dermatitis (AD) affects 2%-10% of adults worldwide. Occurrence and severity of symptoms and treatment success vary among patients. To determine disease severity, burden, and treatment use and satisfaction in […]

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Depression treatment initiation among patients with versus without chronic pain.

The purpose of this study was to examine the extent to which the presence of chronic non-cancer pain (CNCP) impacts the likelihood that patients with diagnoses of depression will initiate […]

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Novel Migraine Treatments: A Review.

To present a review of the mechanisms of action, available clinical data, and safety profiles of novel migraine therapeutics to inform practice. PubMed, Medline, and Google Scholar were searched for […]

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Elevated prelimbic cortex-to-basolateral amygdala circuit activity mediates comorbid anxiety-like behaviors in chronic pain.

Chronic pain could cause both hyperalgesia and anxiety symptoms. How the two components are encoded in the brain remains unclear. The prelimbic cortex (PrL), a critical brain region for both […]

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