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Risk of Attempted and Completed Suicide in Persons Diagnosed With Headache.

Although past research suggests an association between migraine and attempted suicide, there is limited research regarding risk of attempted and completed suicide across headache disorders.

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Deciphering cartilage neuro-immune interactions and innervation profile through 3D engineered osteoarthritic micropathophysiological system.

Osteoarthritis (OA) is an inflammatory musculoskeletal disorder that results in cartilage breakdown and alterations in the surrounding tissue microenvironment. Imbalances caused by inflammation and catabolic processes potentiate pathological nerves and […]

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Pharmacologic Management of Acute Pain in Children: A Systematic Review and Network Meta-Analysis.

Several pharmacologic options exist for the management of acute pediatric pain; however, their comparative effectiveness remains uncertain.

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Research hotspots and trends of acupoint and pain based on PubMed: a bibliometric analysis.

Acupoint-related interventions are the widely utilized modalities in traditional Chinese medicine for the alleviation of pain. This study aims to identify research hotspots and trends by conducting a bibliometric analysis […]

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Moxibustion Alleviates Inflammation via SIRT5-mediated Post-translational Modification and Macrophage Polarization.

Macrophage polarisation is influenced by Sirtuin5 (SIRT5), which is crucial for regulating anti-inflammatory processes. Moxibustion, a traditional Chinese medicine therapy, exerts anti-inflammatory effects by altering the succinate/α-ketoglutarate (α-KG) ratio, an […]

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Understanding Role of Maternal Separation in Depression, Anxiety,and Pain Behaviour: A Mini Review of Preclinical Research With Focus on Neuroinflammatory Pathways.

Contact between mother and child is essential for the proper development of an infant’s physiological systems, brain maturation and behavioural outcomes. Early life stress (ELS), which includes factors such as […]

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Limitations in research on chronic pain and cancer survivors.

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Decomposing the genetic background of chronic back pain.

Chronic back pain (CBP) is a disabling condition with a lifetime prevalence of 40% and a substantial socioeconomic burden. Because of the high heterogeneity of CBP, subphenotyping may help to […]

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Systematic review and meta-analysis of conventional medical management in a patient population with refractory chronic pain suitable to receive a spinal cord stimulation system.

The aim of this review was to systematically identify all evidence that used conventional medical management (CMM) as a comparator in randomised controlled trials (RCTs) of spinal cord stimulation (SCS) […]

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Narrative review of the efficacy and safety of the high-concentration (179mg) capsaicin patch in peripheral neuropathic pain with recommendations for clinical practice and future research.

High-concentration capsaicin patch (HC capsaicin patch) is a locally acting treatment option for adults with peripheral neuropathic pain (pNeP) of various etiologies. Numerous clinical trials, post hoc analyses, and meta-analyses […]

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