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The role of time interval elimination on pain control of preterm infants by sucrose administration.

The 2-min time interval of sucrose administration given before minor painful procedures in preterm infants is based on a few limited studies. We aimed to assess availability of sucrose analgesia […]

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Red induces hyperalgesia and white induces hypoalgesia regardless of pain modality.

Colors are an important factor that influences different aspects of people’s lives. However, little is known about the effects of colors on pain. This preregistered study aimed to investigate whether […]

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Opportunistic Extraction of Quantitative CT Biomarkers: Turning the Incidental Into Prognostic Information.

The past two decades have seen a significant increase in the use of CT, with a corresponding rise in the mean population radiation dose. This rise in CT use has […]

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Safety of topical medications in the management of pediatric atopic dermatitis: an updated systematic review.

There have been new topical agents developed for the treatment of atopic dermatitis in recent years. This systematic review is intended to synthesize the clinical trial literature and concisely report […]

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Celecoxib alleviates nociceptor sensitization mediated by interleukin-1beta-primed annulus fibrosus cells.

This study aims to analyze the effect of pro-inflammatory cytokine-stimulated human annulus fibrosus cells (hAFCs) on the sensitization of dorsal root ganglion (DRG) cells. We further hypothesized that celecoxib (cxb) […]

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The association between chronic venous disease and knee osteoarthritis.

Chronic venous disease (CVD) and knee osteoarthritis (KOA) are two common diseases in the elderly. Both share common risk factors, such as age, sex, and obesity, and are believed to […]

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Chinese and Indian interpretations of pain: A qualitative evidence synthesis to facilitate chronic pain management.

People from minority ethnicities often have a greater impact of chronic pain, are underrepresented at pain services, and may not benefit from treatment to the same extent as dominant cultures. […]

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Tramadol/paracetamol treatment attenuates the development of collagen antibody-induced arthritis and interferes with prednisolone treatment in mice.

The collagen antibody-induced arthritis (CAIA) model is highly effective in inducing arthritis, making it an attractive model for screening therapeutic compounds such as glucocorticoids (GCs). The severity of discomfort in […]

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Recent Progress in Selective COX-2 Inhibitor Formulations and Therapeutic Applications- A Patent Review (2012-2022).

Cyclooxygenase (COX), in literature, known as prostaglandin-endoperoxide synthase (PTGS), is an enzyme that is responsible for the formation of prostanoids, including thromboxane and prostaglandins from arachidonic acid. COX-1 does housekeeping […]

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Novel expression of major histocompatibility complex II in dorsal root ganglion neurons attenuates paclitaxel-induced cold hypersensitivity in male and female mice.

Chemotherapy is often a life-saving cancer treatment, but the development of intractable pain caused by chemotherapy-induced peripheral neuropathy (CIPN) is a major dose-limiting toxicity that restricts cancer survival rates. Recent […]

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