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LncRNA Kcnq1ot1 relieves neuropathic pain through downregulation of Myd88.

Long non-coding RNAs (lncRNAs) have already been documented to become the therapeutic targets for neuropathic pain. Here, this work focused on exploring the specific mechanism underlying Kcnq1 overlapping transcript 1 […]

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Benefits and implications of integrating artificial intelligence in manuscripts submitted to Headache.

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Social cognition in chronic migraine with medication overuse: a cross-sectional study on different aspects of mentalization and social relationships.

Social cognition refers to all mental operations to decipher information needed in social interactions. Here we aimed to outline the socio-cognitive profile of Chronic Migraine with Medication Overuse (CM + MO), given […]

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A systematic review and meta-analysis of randomized control trials: efficacy of cognitive behavioral therapies for the management of functional and recurrent abdominal pain disorders in children and adolescents.

Cognitive behavioral therapy (CBT) is effective for pain relief in children and adolescents with functional abdominal pain disorders (FAPDs). However, few studies have focused on the FAPDs specifically and the […]

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Recent progress on anti-nociceptive effects of carbon monoxide releasing molecule-2 (CORM-2).

The role of carbon monoxide (CO) has evolved albeit controversial disputes on its toxicity. This biological gasotransmitter participates in the endogenous regulation of neurotransmitters and neuropeptides released in the nervous […]

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The role of arachnoid granulations in idiopathic intracranial hypertension.

Idiopathic intracranial hypertension (IIH) is a disease defined by elevated intracranial pressure (ICP) without an established etiology. Arachnoid granulations (AG) are conduits for CSF resorption from the subarachnoid space to […]

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The NLRP3 inflammasome: role in the pathobiology of chronic pain.

Chronic pain is not only one of the most common health problems, it is often challenging to treat adequately. Chronic pain has a high prevalence globally, affecting approximately 20% of […]

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Mediators of digital depression prevention in patients with chronic back pain: Findings from a multicenter randomized clinical trial.

The mechanisms of change in digital interventions for the prevention of depression are largely unknown. Here, we explored whether five theoretically derived intervening variables (i.e., pain intensity, pain-related disability, pain […]

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An artificial intelligence-powered, patient-centric digital tool for self-management of chronic pain: A prospective, multicenter clinical trial.

To investigate how a behavioral health, artificial intelligence (AI)-powered, digital self-management tool affects the daily functions in adults with chronic back and neck pain.

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The bidirectional association between chronic musculoskeletal pain and sleep-related problems: a systematic review and meta-analysis.

This systematic review and meta-analysis synthesize the evidence on the prospective bidirectional associations between sleep-related problems (SRP) and chronic musculoskeletal pain (CMP).

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