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Remifentanil does not affect human microglial immune activation in response to pro-inflammatory cytokines.

Remifentanil is a potent ultra-short acting μ-opioid analgesic drug, frequently used in anaesthesia due to its favorable pharmacodynamic and pharmacokinetic profile. It may be associated with the occurrence of hyperalgesia. […]

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Daily briefing: Brain implants reveal first view of chronic pain.

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Differential Structural Brain Changes Between Responders and Nonresponders After Physical Exercise Therapy for Chronic Nonspecific Neck Pain.

Physical exercise therapy is effective for some people with chronic nonspecific neck pain but not for others. Differences in exercise-induced pain-modulatory responses are likely driven by brain changes. We investigated […]

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Primary somatosensory cortex bidirectionally modulates sensory gain and nociceptive behavior in a layer-specific manner.

The primary somatosensory cortex (S1) is a hub for body sensation of both innocuous and noxious signals, yet its role in somatosensation versus pain is debated. Despite known contributions of […]

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Specific regulation of mechanical nociception by Gβ5 involves GABA-B receptors.

Mechanical, thermal, and chemical pain sensation is conveyed by primary nociceptors, a subset of sensory afferent neurons. The intracellular regulation of the primary nociceptive signal is an area of active […]

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The Association Between Periodontal Disease and Chronic Migraine: A Systematic Review.

Migraine is a neurologic illness that produces intense throbbing pain on one side of the head and affects roughly 1 billion people worldwide. Recent research indicates a relationship between periodontitis […]

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Genetic risk shared across 24 chronic pain conditions: identification and characterization with genomic structural equation modeling.

Chronic pain conditions frequently co-occur, suggesting common risks and paths to prevention and treatment. Previous studies have reported genetic correlations among specific groups of pain conditions and reported genetic risk […]

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Post-COVID Patients With New-Onset Chronic Pain 2 Years After Infection: Cross-Sectional Study.

Although pain is common in non-hospitalized post-COVID-19 syndrome, only a few studies have provided information on the pain experience of these patients.

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Could efficacy at 1 week after galcanezumab administration for patients with migraine predict responders at 3 months? A real world study.

In real-world studies, it is unclear whether galcanezumab has a significant effect in the first week after administration.

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Machine Learning in Spinal Cord Stimulation for Chronic Pain.

Spinal cord stimulation (SCS) is an effective treatment for chronic neuropathic pain. The success of SCS is dependent on candidate selection, response to trialing, and programming optimization. Owing to the […]

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