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Outcomes of targeted muscle reinnervation (TMR) and regenerative peripheral nerve interface (RPNI) in the oncologic population are limited. We sought to examine the safety and effectiveness of TMR and RPNI […]
Learn More >Chronic pain and depression diagnoses are skyrocketing. There is an urgent need for more effective treatments. Ketamine was recently established to alleviate pain and depression, but many gaps remain in […]
Learn More >Innocuous cooling of the skin activates cold-specific Aδ fibres, and hence, the recording of cold-evoked potentials (CEPs) may improve the objective assessment of human thermo-nociceptive function. While the feasibility of […]
Learn More >Zolmitriptan (ZT) is a potent second generation triptan, commonly administered to alleviate migraine attacks. ZT suffers various limitations; massive hepatic first pass metabolism, P-gp efflux transporters susceptibility, and limited (≈40%) […]
Learn More >Gut microbiota in chronic pain: Novel insights into mechanisms and promising therapeutic strategies.
Chronic pain remains one of the world’s most persistent and unsolved clinical challenges that severely affect patients’ quality of life. Presently, considering that the mechanisms underlying chronic pain are not […]
Learn More >As with fibromyalgia, several musculoskeletal disorders are characterized by chronic pain, raising a clinical question – do the instruments used to assess fibromyalgia symptoms according to ACR criteria (ACR criteria) […]
Learn More >Multivariate longitudinal data are used in a variety of research areas not only because they allow to analyze time trajectories of multiple indicators, but also to determine how these trajectories […]
Learn More >The main objective of this clinical practice guideline is to provide a series of recommendations for healthcare and exercise professionals, such as neurologists, physical therapists, and exercise physiologists, regarding exercise […]
Learn More >Although fatigue is common in inflammatory bowel disease (IBD), its pathogenesis remains unclear. This study aimed to determine the prevalence of fatigue and its associated factors in a cohort of […]
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Issues in patient cohort, surrogate outcome measures and conflicts of interest of JAMA Neurology’s Dhruva et al. propensity-matched retrospective evaluation of a single insurer administrative claims data of spinal cord stimulation compared with conventional medical therapy for chronic pain.