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Perampanel ameliorates nitroglycerin-induced migraine through inhibition of the cAMP/PKA/CREB signaling pathway in the trigeminal ganglion in rats.

Perampanel, a highly selective glutamate AMPA receptor antagonist, is widely used to treat epilepsy. Since the existence of common pathophysiological features between epilepsy and migraine, the aim of this study […]

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Antimicrobial therapies for chronic pain (part 2): the prevention and treatment of chronic pain.

The discovery and development of antimicrobial therapies represents one of the most significant advancements in modern medicine. Although the primary therapeutic intent of antimicrobials is to eliminate their target pathogens, […]

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Antimicrobial therapies for chronic pain (part 1): analgesic mechanisms.

There is increasing evidence that the relationship between chronic pain and infections is complex and intertwined. Bacterial and viral infections can cause pain through numerous mechanisms such as direct tissue […]

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Activation of the N-Methyl-D-Aspartate Receptor and Calcium/Calmodulin-Dependent Protein kinase IIαSignal in the Rostral Anterior Cingulate Cortex is Involved in Pain-Related Aversion in Rats with Peripheral Nerve Injury.

The rostral anterior cingulate cortex (rACC) of rat brain is associated with pain-related emotions. However, the underlying molecular mechanism remains unclear. Here, we investigated the effects of the N-methyl-D-aspartate (NMDA) […]

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Suggestion Timing Moderates the Effects of Prior Pain Experiences on Pain Perception.

Two common elements in patient care are reoccurring painful events (e.g., blood draws) and verbal suggestions from others for lessened pain. Research shows that verbal suggestions for lower pain can […]

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Clinical, Neurophysiologic, and Pathologic Features in Patients With Early Onset Post-Radiation Neuropathy.

To study early-onset radiation-induced neuropathy reviewing neurologic course, steroid-response, and available nerve biopsies.

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Migraine prevention: initial treatment options.

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A qualitative exploration of chronic pain management of older adults in remote and rural settings.

The World Health Organization predicts that the number of older adults will nearly double between 2015 and 2050. Older adults are at a higher risk of developing medical conditions such […]

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Effect of static magnetic field therapy on diabetic neuropathy and quality of life: a double-blind, randomized trial.

Diabetic peripheral neuropathy (DPN) is a common complication of diabetes mellitus (DM) that can cause annoying symptoms. To address this condition, several treatment approaches have been proposed, including static magnetic […]

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A Brief Review on the Novel Therapies for Painful Diabetic Neuropathy.

Almost half of people diagnosed with diabetes mellitus will develop painful diabetic neuropathy (PDN), a condition greatly impacting quality of life with complicated pathology. While there are different FDA approved […]

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