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Inflammatory Blood Signature Related to Common Psychological Comorbidity in Chronic Pain.

Chronic pain is characterized by high psychological comorbidity, and diagnoses are symptom-based due to a lack of clear pathophysiological factors and valid biomarkers. We investigate if inflammatory blood biomarker signatures […]

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Autologous Fat Grafting is not Superior to Placebo as Treatment of Postherpetic Neuralgia A Double-Blinded Randomized Clinical Trial.

Postherpetic neuralgia (PHN) is a chronic pain syndrome occurring after a herpes zoster (HZ) outbreak, also known as shingles. Treatment is complex, and no effective treatment exists today. Autologous fat […]

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Spinal Interferon Regulatory Factor 8 and Brain-derived Neurotrophic Factor in the Prefrontal Cortex are Involved in Pain-induced Depression Relief via Ultrasound-guided Pulsed Radiofrequency in a Rat Spared Nerve Injury Model.

Pain-depression comorbidity has become a great burden to individuals and society. Nevertheless, the mechanisms underlying comorbid diseases have still not been fully revealed. Ultrasound-guided pulsed radiofrequency (PRF) on peripheral nerves, […]

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The Effectiveness of Psychological Interventions for Rheumatoid Arthritis (RA): A Systematic Review and Meta-Analysis.

Rheumatoid arthritis (RA) is a long-term disorder that significantly impairs somatic, emotional, and psychological functioning. The objective of this review is to identify, appraise, and synthesize the effects of psychological […]

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The Biology of Stress Intolerance in Patients with Chronic Pain-State of the Art and Future Directions.

Stress has been consistently linked to negative impacts on physical and mental health. More specifically, patients with chronic pain experience stress intolerance, which is an exacerbation or occurrence of symptoms […]

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IL-1 Mediates Chronic Stress-Induced Hyperalgesia Accompanied by Microglia and Astroglia Morphological Changes in Pain-Related Brain Regions in Mice.

Chronic stress causes several pain conditions including fibromyalgia. Its pathophysiological mechanisms are unknown, and the therapy is unresolved. Since the involvement of interleukin-1 (IL-1) has been described in stress and […]

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CAPER: Patient Preferences to Inform Non-Surgical Treatment of Chronic Low Back Pain (cLBP): A Discrete Choice Experiment.

We developed and used a discrete-choice measure to study patient preferences of risks and benefits of non-surgical treatments making cLBP treatment selections.

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The role of expectations, control and reward in the development of pain persistence based on a unified model.

Chronic, or persistent pain affects more than 10% of adults in the general population. This makes it one of the major physical and mental health care problems. Although pain is […]

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Cannabinoid Therapy: Attitudes and Experiences of People With Chronic Pain.

Clinical trials of cannabinoids for chronic pain have mixed and often inconclusive results. In contrast, many prospective observational studies show analgesic effects of cannabinoids. This survey study aimed to examine […]

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Higher self-perceived stress reactivity is associated with increased chronic pain risk.

Experiencing stress can contribute to unfavorable pain experiences, but outcomes vary across individuals. Evidence suggests that a person’s specific reactivity to stressful events may influence pain responses. Previous studies measuring […]

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