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Brain system segregation and pain catastrophizing in chronic pain progression.

Pain processing involves emotional and cognitive factors that can modify pain perception. Increasing evidence suggests that pain catastrophizing (PC) is implicated, through pain-related self-thoughts, in the maladaptive plastic changes related […]

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Telehealth for management of chronic non-cancer pain and opioid use disorder in safety net primary care.

The SARS-CoV-2 (COVID-19) pandemic increased use of telehealth for the management of opioid use disorder and chronic non-cancer pain in primary care safety net clinical systems. Significant barriers to telehealth […]

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Headache impact and socioeconomic status: findings from a study of the German Migraine and Headache Society (DMKG).

Headache disorders are not only among the most prevalent, they are also among the most disabling disorders worldwide. This paper investigates the association between headache impact on daily life and […]

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Early and Recent Exposure to Adversity, TLR-4 Stimulated Inflammation, and Diurnal Cortisol in Women with Interstitial Cystitis/Bladder Pain Syndrome: A MAPP Research Network Study.

Both early (ELA) and recent life adversity (RLA) have been linked with chronic pain conditions and persistent alterations of neuroendocrine and inflammatory responses. Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS) is a […]

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Virtual Reality Intervention for Patients With Neck Pain: Systematic Review and Meta-analysis of Randomized Controlled Trials.

Neck pain is a prevalent condition that causes an enormous health care burden due to the lack of efficient therapies. As a promising technology, virtual reality (VR) has shown advantages […]

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DNMT1 mediates chronic pain-related depression by inhibiting GABAergic neuronal activation in central amygdala.

Chronic pain can induce depressive emotion. DNA methyltransferases (DNMTs) have been shown to be involved in the development of chronic pain and depression. However, the role and mechanism of DNMTs […]

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Modelling and classifying joint trajectories of self-reported mood and pain in a large cohort study.

It is well-known that mood and pain interact with each other, however individual-level variability in this relationship has been less well quantified than overall associations between low mood and pain. […]

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Effect Of A Behavioural Therapy-Based Virtual Reality Application On Quality Of Life In Chronic Low Back Pain.

Low back pain is the leading cause of years lived with disability with a large impact on quality of life and resistant to a broad array of current treatments. This […]

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Chronic pain patients low in social connectedness report higher pain and need deeper pressure for pain relief.

The experience of rejection and disconnection reliably amplifies pain. Yet, little is known about the impact of enduring feelings of closeness, or social connectedness, on experiences of chronic pain. The […]

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Role of Glutamatergic Projections from Lateral Habenula to Ventral Tegmental Area in Inflammatory Pain-Related Spatial Working Memory Deficits.

The lateral habenula (LHb) and the ventral tegmental area (VTA), which form interconnected circuits, have important roles in the crucial control of sensory and cognitive motifs. Signaling in the LHb-VTA […]

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