DNMT1 mediates chronic pain-related depression by inhibiting GABAergic neuronal activation in central amygdala.
Ding X, Lin Y, Chen C, Yan B, Liu Q, Zheng H, Wu Y, Zhou C
Chronic pain can induce depressive emotion. DNA methyltransferases (DNMTs) have been shown to be involved in the development of chronic pain and depression. However, the role and mechanism of DNMTs in chronic pain-induced depression are not well understood.