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Efficacy and safety of intranasal agents for the acute treatment of migraine: a systematic review and network meta-analysis.

Intranasal agents may be ideal for the treatment of migraine patients. Many new acute intranasal-specific therapies have been developed, but few of them have been directly compared. The aim of […]

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European Headache Federation (EHF) critical re-appraisal and meta-analysis of oral drugs in migraine prevention-part 2: flunarizine.

Novel disease-specific and mechanism-based treatments sharing good evidence of efficacy for migraine have been recently marketed. However, reimbursement by insurers depends on treatment failure with classic anti-migraine drugs. In this […]

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Migraines and cardiovascular disease: mechanisms and methodological challenges.

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Is headache a risk factor for dementia? A systematic review and meta-analysis.

In this systematic review and meta-analysis, we critically evaluate available evidence regarding the association between primary headaches and subsequent decline of cognitive function and dementia.

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Adverse event profile of CGRP monoclonal antibodies: findings from the FDA adverse event reporting database.

Four CGRP Monoclonal Antibodies (mAbs) have been approved for migraine prophylaxis by the Food and Drug Administration (FDA) since 2018. However, there are concerns about the safety of these four […]

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The association between multiple sclerosis and migraine: A meta-analysis.

Multiple sclerosis (MS) is a chronic progressive condition marked by the deterioration of myelin and impairment of neurological function. The global prevalence of MS is approximately 2.2 million. Migraines are […]

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Migraine in older adults.

Migraine is an evolving, and sometimes lifelong disorder. The prevalence of episodic migraine peaks among individuals aged in their late 30s, implying a tendency for the disorder to remit with […]

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Quality of life in children suffering from headaches: a systematic literature review.

Headaches are the most common complaints among pediatric populations. Determining the cause and appropriate treatment for headaches may be challenging and costly, and the impact of headaches on the lives […]

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Global, regional, and national epidemiology of migraine and tension-type headache in youths and young adults aged 15-39 years from 1990 to 2019: findings from the global burden of disease study 2019.

In recent years, headache disorders have garnered significant attention as a pressing global health issue. This concern is especially pronounced in low- to middle-income countries and exhibits a notable increase […]

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PACAP38-related modulation of the cranial parasympathetic projection: a novel mechanism and therapeutic target in severe primary headache.

Little is known of how the presence of cranial autonomic symptoms (CAS) in cluster headache and migraine may contribute to their severe headache phenotype. However, this strong association points to […]

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