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Cluster headache is one of the most intensely painful human conditions: Results from the International Cluster Headache Questionnaire.

To determine the pain intensity of cluster headache through a large survey by comparing it to other painful disorders. Furthermore, to investigate the relationship between maximal pain, autonomic, and other clinical symptoms, as well as demographic attributes of cluster headache.

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Headache at onset of first-ever ischemic stroke: clinical characteristics and predictors.

No studies have prospectively investigated headache at onset of first-ever ischemic stroke, along with a large concurrent control group. Our aims were to answer two important questions: 1) are headaches at stroke onset causally related to the stroke and what are their typical clinical characteristics? 2) what aetiology of stroke is associated with these headaches?

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Dependence-like behaviour in patients treated for medication overuse headache: A prospective open-label randomized controlled trial.

Dependence-like behaviour may complicate withdrawal and increase risk of relapse of medication overuse headache (MOH). The most effective treatment for reducing dependence-like behaviour is unknown.

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Burden of increasing opioid use in the treatment of migraine: Results from the Migraine in America Symptoms and Treatment Study.

We sought to assess factors associated with the frequency of self-reported prescription opioid use in persons with migraine, including demographic variables, comorbidities, headache characteristics, and patterns of consultation.

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A non-convulsant delta-opioid receptor agonist, KNT-127, reduces cortical spreading depression and nitroglycerin-induced allodynia.

The aim of this study was to determine if the non-convulsant delta-opioid receptor (DOR) agonist, KNT-127, could inhibit migraine-associated endpoints.

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Noninvasive Neuromodulation in Migraine.

The past two decades has seen an influx of noninvasive neuromodulation devices aimed at treatment of various primary headache disorders, including cluster headache and migraine. This narrative review is to summarize the current options in noninvasive neuromodulation in migraine.

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Hypersensitivity to calcitonin gene-related peptide in chronic migraine.

To investigate if calcitonin gene-related peptide infusion induces migraine-like attacks in chronic migraine patients.

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Oral rimegepant for preventive treatment of migraine: a phase 2/3, randomised, double-blind, placebo-controlled trial.

Rimegepant is a calcitonin gene-related peptide receptor antagonist that has shown efficacy and safety in the acute treatment of migraine. We aimed to compare the efficacy of rimegepant with placebo for preventive treatment of migraine.

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Oral rimegepant for migraine prevention.

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Effectiveness of Mindfulness Meditation vs Headache Education for Adults With Migraine: A Randomized Clinical Trial.

Migraine is the second leading cause of disability worldwide. Most patients with migraine discontinue medications due to inefficacy or adverse effects. Mindfulness-based stress reduction (MBSR) may provide benefit.

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