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Excessive production of hydrogen peroxide in mitochondria contributes to atopic dermatitis.

Atopic dermatitis (AD) is a complex disease characterized by chronic recurring eczema and pruritus. In addition, AD patients display increased cutaneous and systemic levels of oxidative damage markers, whose source […]

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Emerging Systemic Treatments for Atopic Dermatitis.

Atopic dermatitis (AD) is a chronic or chronically relapsing inflammatory skin disease which results from a complex, multifaceted interaction between environmental factors in genetically predisposed patients. Epidermal barrier impairment, alteration […]

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Safety of topical medications in the management of pediatric atopic dermatitis: an updated systematic review.

There have been new topical agents developed for the treatment of atopic dermatitis in recent years. This systematic review is intended to synthesize the clinical trial literature and concisely report […]

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Efficacy and Safety of Tralokinumab in Adolescents With Moderate to Severe Atopic Dermatitis: The Phase 3 ECZTRA 6 Randomized Clinical Trial.

Safe and effective long-term treatments for adolescents with moderate to severe atopic dermatitis (AD) are limited.

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Treat-to-target in the management of moderate-to-severe atopic dermatitis in adults: A Canadian perspective.

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Neurotrophins: Neuroimmune Interactions in Human Atopic Diseases.

Allergic diseases are accompanied by a variety of symptoms such as pruritus, coughing, sneezing, and watery eyes, which can result in severe physiological and even psychological impairments. The exact mechanisms […]

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Understanding the physiological role of Na1.9: Challenges and opportunities for pain modulation.

Voltage-activated Na (Na) channels are crucial contributors to rapid electrical signaling in the human body. As such, they are among the most targeted membrane proteins by clinical therapeutics and natural […]

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Characterization of a Perturbed Skin Microbiome in Prurigo Nodularis and Lichen Simplex Chronicus.

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GABAergic neurons in the ventral lateral geniculate nucleus and intergeniculate leaflet are involved in itch processing in mice.

Itch and pain are two closely related sensations that receiving similar encodings at multiple levels. Accumulated evidences suggest that activation of the ventral lateral geniculate nucleus and intergeniculate leaflet (vLGN/IGL)-to-lateral […]

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Overview of Atopic Dermatitis in Different Ethnic Groups.

Atopic dermatitis (AD) is a common chronic inflammatory skin disease with a high prevalence worldwide, including countries from Asia, Africa, and Latin America, and in different ethnic groups. In recent […]

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