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Papers of the Week

Home / Publications / Pain Research Forum / Papers of the Week / Electroacupuncture ameliorates knee osteoarthritis in rats via inhibiting NLRP3 inflammasome and reducing pyroptosis.

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Papers: 10 Dec 2022 - 16 Dec 2022


Animal Studies


2022 Dec 12


Mol Pain


http://www.ncbi.nlm.nih.gov/pubmed/36510338?dopt=Abstract

Electroacupuncture ameliorates knee osteoarthritis in rats via inhibiting NLRP3 inflammasome and reducing pyroptosis.

Authors

Electroacupuncture ameliorates knee osteoarthritis in rats via inhibiting NLRP3 inflammasome and reducing pyroptosis.
Zhang W, Zhang L L, Yang S, Wen B, Chen J, Chang J
Mol Pain. 2022 Dec 12:17448069221147792.
PMID: 36510338.

Abstract

Knee Osteoarthritis (KOA), is the most common joint disease worldwide. The pathogenesis of KOA is complex and electroacupuncture (EA) is an effective therapy for KOA, but the mechanism remains unclear. In this study, we aim to investigate the potential therapeutic effect of EA on the rat model of KOA induced by monosodium iodoacetate (MIA) and its relationship with NLRP3 inflammasome by immunohistochemistry and western blot.
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