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Papers of the Week


2022 Jun 30


Br J Pharmacol

Scutellarein Attenuates Atopic Dermatitis by Selectively Inhibiting Transient Receptor Potential Vanilloid 3.

Authors

Wang Y, Tan L, Jiao K, Xue C, Tang Q, Jiang S, Ren Y, Chen H, Abd El-Aziz T M, Abdelazeem KNM, Yu Y, Zhao F, Zhu MX, Cao Z
Br J Pharmacol. 2022 Jun 30.
PMID: 35771623.

Abstract

Atopic dermatitis (AD) is one of the most common chronic inflammatory cutaneous diseases with unmet clinical needs. As a common ingredient found in several medicinal herbs with efficacy on cutaneous inflammatory diseases, Scutellarein (Scu) has been shown to possess anti-inflammatory and anti-proliferative activities. We aimed to evaluate the therapeutic efficacy of Scu against AD and its underlying molecular mechanism.