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Papers of the Week

Home / Publications / Pain Research Forum / Papers of the Week / Sinapic Acid Inhibits IL-1β-Induced Apoptosis and Catabolism in Nucleus Pulposus Cells and Ameliorates Intervertebral Disk Degeneration.

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2020


J Inflamm Res


http://www.ncbi.nlm.nih.gov/pubmed/33209047?dopt=Abstract


13

Sinapic Acid Inhibits IL-1β-Induced Apoptosis and Catabolism in Nucleus Pulposus Cells and Ameliorates Intervertebral Disk Degeneration.

Authors

Sinapic Acid Inhibits IL-1β-Induced Apoptosis and Catabolism in Nucleus Pulposus Cells and Ameliorates Intervertebral Disk Degeneration.
Huang J-F, Zheng X-Q, Lin J-L, Zhang K, Tian H-J, Zhou W-X, Wang H, Gao Z, Jin H-M, Wu A-M
J Inflamm Res. 2020; 13:883-895.
PMID: 33209047.

Abstract

Low back pain (LBP) is a very common condition and leads to serious pain, disability, and price tag all over the world. Intervertebral disk degeneration (IDD) is one of the major reasons that contributed to LBP. The levels of interleukin 1 beta (IL-1β) increase significantly in degenerative disks. IL-1β also accelerates IDD. Sinapic acid (SA) has the effect of anti-inflammatory, antioxidant and antimicrobial. However, the effect of SA on IDD has never been studied. Therefore, the aim of this study was to figure out whether SA has protective effect on nucleus pulposus (NP) cells and further explore the possible underlying mechanism.
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