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Papers of the Week


Papers: 17 Oct 2020 - 23 Oct 2020


Human Studies, Pharmacology/Drug Development


2020 Oct 20


Clin J Pain

A Three-Way Crossover Study of Pregabalin, Placebo and the Histamine 3 Receptor Inverse Agonist AZD5213 in Combination with Pregabalin in Subjects with Painful Diabetic Neuropathy and Good Pain-Reporting Ability.

Abstract

In this study, patients with painful diabetic neuropathy (PDN) were trained using an experimental pain paradigm in an attempt to enroll a subset of patients who are "pain connoisseurs" and therefore more able to discriminate between active and placebo treatments.