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Papers of the Week


2020 Sep 16


Arch Oral Biol


119

Sumatriptan alleviates radiation-induced oral mucositis in rats by inhibition of NF-kB and ERK activation, prevention of TNF-α and ROS release.

Authors

Ala M, Mohammad Jafari R, Ala M, Agbele A T, Hejazi S M, Tavangar S M, Mahdavi S R M, Dehpour A R
Arch Oral Biol. 2020 Sep 16; 119:104919.
PMID: 32977152.

Abstract

Oral mucositis caused by radiation therapy is a common problem in cancer patients, especially those with head and neck cancer. Numerous experimental and clinical studies have attempted to find a drug to alleviate oral mucositis. Sumatriptan, is conventionally used to treat migraine attack and cluster headache. Recently, low doses have been shown to have anti-inflammatory properties. In this study we aimed to measure the effect of sumatriptan on experimental radiotherapy-induced oral mucositis.