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Papers of the Week


Papers: 15 Aug 2020 - 21 Aug 2020


Pharmacology/Drug Development

PAIN TYPE:
Itch


2020 09


Anesthesiology


133


3

Editor's Pick

Computer-aided Discovery of a New Nav1.7 Inhibitor for Treatment of Pain and Itch.

Authors

Chandra S, Wang Z, Tao X, Chen O, Luo X, Ji R-R, Bortsov AV
Anesthesiology. 2020 09; 133(3):611-627.
PMID: 32788559.

Abstract

Voltage-gated sodium channel Nav1.7 has been validated as a perspective target for selective inhibitors with analgesic and anti-itch activity. The objective of this study was to discover new candidate compounds with Nav1.7 inhibitor properties. The authors hypothesized that their approach would yield at least one new compound that inhibits sodium currents in vitro and exerts analgesic and anti-itch effects in mice.