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Papers of the Week


2020 Mar 24


J Clin Med


9


3

Aryl Hydrocarbon Receptor Activation Downregulates IL-33 Expression in Keratinocytes via Ovo-Like 1.

Authors

Tsuji G, Hashimoto-Hachiya A, Yen V H, Miake S, Takemura M, Mitamura Y, Ito T, Murata M, Furue M, Nakahara T
J Clin Med. 2020 Mar 24; 9(3).
PMID: 32214018.

Abstract

IL-33, one of the IL-1 superfamily cytokines, has been shown to be associated with pruritus and inflammation in atopic dermatitis (AD). Furthermore, IL-33 production derived from keratinocytes reportedly has a crucial role in the development of AD; however, the mechanism of IL-33 expression has not been fully understood.