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Papers of the Week

Home / Publications / Pain Research Forum / Papers of the Week / Pharmacokinetics and Bioequivalence Evaluation of a New Oxycodone Tamper-Resistant Tablet Administered with an Opioid Antagonist in Patients with Chronic Pain.

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2020 Feb


Clin Drug Investig


http://www.ncbi.nlm.nih.gov/pubmed/31679120?dopt=Abstract


40


2

Pharmacokinetics and Bioequivalence Evaluation of a New Oxycodone Tamper-Resistant Tablet Administered with an Opioid Antagonist in Patients with Chronic Pain.

Authors

Pharmacokinetics and Bioequivalence Evaluation of a New Oxycodone Tamper-Resistant Tablet Administered with an Opioid Antagonist in Patients with Chronic Pain.
Luo Z, Miao J, Shu S, Wang Y, Zhu X, Hu C, Shen Y
Clin Drug Investig. 2020 Feb; 40(2):139-148.
PMID: 31679120.

Abstract

Oxycodone tamper resistant (OTR) is a new extended-release abuse-deterrent formulation providing improvements in the tamper resistant characteristics. This study aimed to investigate the pharmacokinetic properties of the new OTR tablets and evaluate the bioequivalence of oxycodone from OTR and the original extended release (ER) formulation tablets administered with an opioid antagonist in patients with chronic pain.
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